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Study on the correlation between dynamic monitoring of peripheral blood cell-related inflammatory indicators and clinical prognosis of traumatic brain injury

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DOI: 10.23977/medbm.2026.040108 | Downloads: 1 | Views: 46

Author(s)

Xiong Yang 1, Weikang Yang 1, Xian Wang 2, Yuan Yao 1

Affiliation(s)

1 Department of Neurosurgery, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China
2 Department of Pharmacy, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China

Corresponding Author

Yuan Yao

ABSTRACT

To explore the correlation between dynamic monitoring of peripheral blood cell-related inflammatory indicators and clinical prognosis of traumatic brain injury, 201 patients with traumatic cerebral hemorrhage were enrolled and divided into good (n=74, mRS 0–2) and poor (n=127, mRS 3–6) prognosis groups based on discharge mRS score. Inflammatory indicators were compared, and multivariate logistic regression was used to identify risk factors. Significant differences were found in age, admission GCS, combined trauma, preoperative PLR and SIRI, postoperative 1d NLR, and 3d NLR and MLR (all P<0.05). Multivariate analysis showed that age (OR=5.018), admission GCS (OR=2.474), preoperative SIRI (OR=2.587), postoperative 3d NLR (OR=2.566), and 3d MLR (OR=3.653) were independent risk factors (all P<0.05). ROC analysis revealed AUCs for preoperative SIRI, 3d NLR, and 3d MLR as 0.612, 0.783, and 0.722, respectively, while the combined logistic model achieved an AUC of 0.868, with higher sensitivity and specificity than any single variable. Preoperative SIRI, postoperative 3d NLR, and 3d MLR are associated with clinical prognosis of traumatic cerebral hemorrhage, and their combination improves predictive performance.

KEYWORDS

Traumatic brain injury, Neutrophil-to-lymphocyte ratio, Monocyte-to-lymphocyte ratio, Platelet-to-lymphocyte ratio, Systemic inflammation response index, Receiver operating characteristic curve

CITE THIS PAPER

Xiong Yang, Weikang Yang, Xian Wang, Yuan Yao. Study on the correlation between dynamic monitoring of peripheral blood cell-related inflammatory indicators and clinical prognosis of traumatic brain injury. MEDS Basic Medicine (2026). Vol. 4, No. 1, 58-65. DOI: http://dx.doi.org/10.23977/medbm.2026.040108.

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