Author(s)

Lin Guangye ¹, Guo Fan ¹, Yang Ye ¹, Deng Shen ¹, Fang Yide ¹

Affiliation(s)

¹ Wuhan Third Hospital, Wuhan, Hubei, 430000, China

Corresponding Author

Fang Yide

ABSTRACT

To observe the clinical efficacy of silk fibroin composite gel in preventing post-inflammatory hyperpigmentation (PIH) and promoting wound healing following 532-nm Q-switched Nd:YAG laser treatment for facial freckles. A total of 123 patients were randomly divided into a composite gel group (n=41, Siruimei Biotechnology), a patch group (n=41, Fangchenggang Ruiyi Biotechnology), and a control group (n=41, ice compress and mupirocin ointment). The results showed that the scab formation time (2.08 ± 0.61 days) and scab shedding time (4.12 ± 0.77 days) in the composite gel group were significantly shorter than those in the patch group and the control group (P<0.001). At 1 month after treatment, the PIH incidence rate in the composite gel group was 36.59%, which was significantly lower than 63.41% in the control group (P<0.05). In conclusion, the application of silk fibroin composite gel after laser surgery can effectively speed up skin healing and reduce PIH. It is better than traditional dressings and has high clinical application value.

KEYWORDS

Silk fibroin hydrogel; Q-switched Nd:YAG laser; Facial ephelides; Post-inflammatory hyperpigmentation; Cutaneous restitution; Biomimetic polymers

CITE THIS PAPER

Lin Guangye, Guo Fan, Yang Ye, Deng Shen, Fang Yide. Clinical application of silk fibroin composite gel in wound repair after laser treatment of freckles. Social Medicine and Health Management (2026). Vol. 7, No.1, 88-91. DOI: http://dx.doi.org/10.23977/socmhm.2026.070112.

REFERENCES

[1] Wu W, Su Q, Zhang Y, et al. Novel 532‐nm Q‐switched Nd: YAG laser for the treatment of melasma and rejuvenation: a prospective, randomized controlled comparison with 1,064‐nm Q‐switched Nd: YAG laser[J]. International Journal of Dermatology, 2024, 63(9): 1242-1251.
[2] Mar K, Maazi M, Khalid B, et al. Prevention of Post‐Inflammatory Hyperpigmentation in Skin of Colour: A Systematic Review[J]. Australasian Journal of Dermatology, 2025, 66(3): 119-126.
[3] Gholipourmalekabadi M, Sapru S, Samadikuchaksaraei A, et al. Silk fibroin for skin injury repair: where do things stand?[J]. Advanced drug delivery reviews, 2020, 153: 28-53.
[4] Mazurek Ł, Szudzik M, Rybka M, et al. Silk fibroin biomaterials and their beneficial role in skin wound healing[J]. Biomolecules, 2022, 12(12): 1852.
[5] Chen Z, Cheng J, Wang M, et al. In situ forming silk fibroin hydrogel dressing accelerates acute wound healing via immunomodulation and extracellular matrix regeneration[J]. Journal of Controlled Release, 2025: 114228.
[6] Li Z, Tan G, Xie H, et al. The application of regenerated silk fibroin in tissue repair[J]. Materials, 2024, 17(16): 3924.
[7] Yan Y, Li M, Guo L, et al. Silk fibroin hydrogel with recombinant silk fibroin/NT3 protein enhances wound healing by promoting type III collagen synthesis and hair follicle regeneration in skin injury[J]. Materials Today Bio, 2025, 33: 101957.

Sponsors, Associates, and Links

---

• Information Systems and Economics
  
  
• Accounting, Auditing and Finance
  
  
• Industrial Engineering and Innovation Management
  
  
• Tourism Management and Technology Economy
  
  
• Journal of Computational and Financial Econometrics
  
  
• Financial Engineering and Risk Management
  
  
• Accounting and Corporate Management
  
  
• Social Security and Administration Management
  
  
• Population, Resources & Environmental Economics
  
  
• Statistics & Quantitative Economics
  
  
• Agricultural & Forestry Economics and Management
  
  
• Land Resource Management
  
  
• Information, Library and Archival Science
  
  
• Journal of Human Resource Development
  
  
• Manufacturing and Service Operations Management
  
  
• Operational Research and Cybernetics