Author(s)

Jake Wang ¹, Ella Wang ¹, Doris Dai ¹

Affiliation(s)

¹ Eternal Grace R&D Center, Gpo Lief Pte. Ltd., Singapore

Corresponding Author

Jake Wang

ABSTRACT

This study evaluated the pharmacokinetic profile of a nano-micellar liquid curcumin formulation (Biowell Lytox+) and its clinical effects on acne-prone skin through a single-dose crossover pharmacokinetic trial and a 12-week clinical evaluation. Pharmacokinetic results showed that, compared with native curcumin powder, the nano-micellar formulation achieved a 193-fold increase in relative bioavailability (p<0.001), reduced Tmax from 7.5 hours to 1.1 hours, and increased Cmax from 7.2 nmol/L to 3450 nmol/L, with notable sex differences (280-fold in females, 118-fold in males). In acne-prone subjects, serum IL-8 decreased by 18.5% within 24 hours. After 12 weeks of daily supplementation, inflammatory lesions decreased by 61.5%, noninflammatory lesions by 42.3%, sebum excretion rate by 52.0%, erythema index by 35.2%, transepidermal water loss by 22.0%, and perifollicular keratin accumulation by 28.0%, while the individual typology angle (ITA°) improved by 23.4%. No adverse events were reported. These findings demonstrate that the nano-micellar liquid curcumin system significantly enhances oral bioavailability and achieves rapid systemic exposure, which translates into multidimensional, progressive clinical improvements in acne-prone skin, supporting its use as a systemic nutritional intervention strategy.

KEYWORDS

Curcumin, bioavailability, nano-micelle, acne vulgaris, inflammation, sebum, erythema

CITE THIS PAPER

Jake Wang, Ella Wang, Doris Dai. Translation of Enhanced Bioavailability of a Nano-Micellar Curcumin Formulation (Biowell Lytox+) into Improved Clinical Outcomes in Acne-Prone Skin: A Pharmacokinetic and Exploratory Clinical Study. MEDS Basic Medicine (2026). Vol. 4, No. 1, 46-51. DOI: http://dx.doi.org/10.23977/medbm.2026.040106.

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