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  4. Vol 6, Issue 1, 2026

Pterostilbene Inhibits Hepatocellular Carcinoma by Regulating the MAPK Signaling Pathway

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DOI: 10.23977/phpm.2026.060108 | Downloads: 1 | Views: 73

Author(s)

Nan Jiang 1, Rulin Ma 1

Affiliation(s)

1 School of Public Health, Shihezi University, Shihezi, Xinjiang, 832003, China

Corresponding Author

Rulin Ma

ABSTRACT

To explore the mechanism by which pterostilbene inhibits hepatocellular carcinoma (HCC), this study adopted the method of network pharmacology. The intersection targets of pterostilbene and HCC were obtained through database screening, the protein-protein interaction (PPI) network was constructed to screen core targets, and then GO functional enrichment analysis and KEGG pathway enrichment analysis were carried out. The results showed that a total of 88 intersection targets and 10 core targets including MAPK1 were identified. These targets were mainly enriched in biological processes such as protein phosphorylation and MAPK cascade reaction, and the core regulatory pathway was the MAPK signaling pathway. This study indicates that pterostilbene may exert anti-HCC effects by targeting and regulating the MAPK signaling pathway through the synergistic action of multiple targets and multiple pathways, which provides a theoretical reference for its subsequent research and application.

KEYWORDS

Pterostilbene; Hepatocellular Carcinoma; MAPK Signaling Pathway; Network Pharmacology; Anti-Hepatoma Mechanism

CITE THIS PAPER

Nan Jiang, Rulin Ma. Pterostilbene Inhibits Hepatocellular Carcinoma by Regulating the MAPK Signaling Pathway. MEDS Public Health and Preventive Medicine (2026). Vol. 6, No.1, 60-66. DOI: http://dx.doi.org/10.23977/phpm.2026.060108.

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