Author(s)

Naizhuang Wang ¹, Yaning Wang ¹, Jingjing Dai ¹

Affiliation(s)

¹ Eternal Grace R&D Center, Gpo Lief Pte. Ltd., Singapore

Corresponding Author

Naizhuang Wang

ABSTRACT

This 12-week randomized, double-blind, placebo-controlled pilot trial evaluated the effects of a novel Phyto Placenta Complex on ovarian physiological function, dermal microstructure, and menopausal symptoms in perimenopausal women aged 45–55 years. Twenty-five participants were randomly assigned to receive either 230 mg/day of the Phyto Placenta Complex (n = 13) or placebo (n = 12). Serum inhibin B levels declined in the placebo group (−12.4% from baseline), whereas levels were maintained in the treatment group (48.5 ± 10.1 pg/mL). Regression analysis indicated a shift toward a younger ovarian physiological profile by approximately 4.7 years relative to chronological age in the treatment group (p < 0.05). Significant improvements were also observed in wrinkle depth, skin hydration, elasticity, and melanin index, as well as a 62.3% reduction in total Modified Kupperman Index scores. These findings suggest that daily supplementation with 230 mg of Phyto Placenta Complex preserves ovarian endocrine function and improves systemic menopausal outcomes, potentially mediated by efficient in vivo conversion to S-equol and ERβ-selective signaling.

KEYWORDS

Phyto Placenta Complex, S-equol, ERβ, Inhibin B, Ovarian Aging, Skin Rejuvenation, Menopause

CITE THIS PAPER

Naizhuang Wang, Yaning Wang, Jingjing Dai, Efficacy of a Novel Phyto Placenta Complex on Ovarian Physiological Age, Dermal Microstructure, and Menopausal Symptoms: A 12-Week Randomized, Double-Blind, Placebo-Controlled Pilot Trial. MEDS Clinical Medicine (2026) Vol. 7: 16-22. DOI: http://dx.doi.org/10.23977/medsc.2026.070103.

REFERENCES

[1] Burger HG, Hale GE, Robertson DM, Dennerstein L. A review of hormonal changes during the menopausal transition: focus on findings from the Melbourne Women's Midlife Health Project. Hum Reprod Update. 2007;13(6):559-565.
[2] Welt CK, McNicholl DJ, Taylor AE, Hall JE. Female reproductive aging is marked by decreased secretion of dimeric inhibin. J Clin Endocrinol Metab. 1999;84(1):105-111.
[3] Burger HG. The endocrinology of the menopause. J Steroid Biochem Mol Biol. 1999 Apr-Jun;69(1-6):31-5.
[4] Muthyala RS, Ju YH, Sheng S, et al. Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and transcriptional activity involving estrogen receptors alpha and beta. Bioorg Med Chem. 2004;12(6):1559-1567.
[5] Jackson RL, Greiwe JS, Schwen RJ. Emerging evidence of the health benefits of S-equol. Nutr Rev. 2011;69(8):432-448.
[6] Setchell KD, Brown NM, Lydeking-Olsen E. The clinical importance of the metabolite equol—a clue to the effectiveness of soy and its isoflavones. J Nutr. 2002;132(12):3577-3584.
[7] Setchell KD, Clerici C. Equol: pharmacokinetics and biological actions. J Nutr. 2010;140(7):1355S–1362S.
[8] Rowland I, Faughnan M, Hoey L, et al. Bioavailability of phyto-oestrogens. Br J Nutr. 2003;89(S1):S45–S58.
[9] Oyama A, Ueno T, Uchiyama S, et al. The effects of natural S-equol supplementation on skin aging in postmenopausal women. Menopause. 2012;19(2):202–210.
[10] Ishiwata N, Melby MK, Mizuno S, et al. New equol supplement for relieving menopausal symptoms: randomized, placebo-controlled trial of Japanese women Menopause. 2009;16(1):141–148.
[11] Sowers MR, Chin D, Santoro N, et al. FSH and inhibin B variability during the menopausal transition. J Clin Endocrinol Metab. 2008;93(9):3465-3471.
[12] Jian Wu, Jun Oka, Mitsuru Higuchi, et al. Cooperative effects of isoflavones and exercise on bone and lipid metabolism in postmenopausal Japanese women: a randomized placebo-controlled trial. Metabolism Clinical and Experimental. 2006; 55: 423-433.
[13] Tao Liu, Nan Li, Yi-qi Yan, et al. Recent advances in the anti-aging effects of phytoestrogens on collagen, water content, and oxidative stress. Phytotherapy Research.2020;34:435-44.

Sponsors, Associates, and Links

---

• Journal of Neurobiology and Genetics
  
  
• Medical Imaging and Nuclear Medicine
  
  
• Bacterial Genetics and Ecology
  
  
• Transactions on Cancer
  
  
• Journal of Biophysics and Ecology
  
  
• Journal of Animal Science and Veterinary
  
  
• Academic Journal of Biochemistry and Molecular Biology
  
  
• Transactions on Cell and Developmental Biology
  
  
• Rehabilitation Engineering & Assistive Technology
  
  
• Orthopaedics and Sports Medicine
  
  
• Hematology and Stem Cell
  
  
• Journal of Intelligent Informatics and Biomedical Engineering
  
  
• MEDS Basic Medicine
  
  
• MEDS Stomatology
  
  
• MEDS Public Health and Preventive Medicine
  
  
• MEDS Chinese Medicine
  
  
• Journal of Enzyme Engineering
  
  
• Advances in Industrial Pharmacy and Pharmaceutical Sciences
  
  
• Bacteriology and Microbiology
  
  
• Advances in Physiology and Pathophysiology
  
  
• Journal of Vision and Ophthalmology
  
  
• Frontiers of Obstetrics and Gynecology
  
  
• Digestive Disease and Diabetes
  
  
• Advances in Immunology and Vaccines
  
  
• Nanomedicine and Drug Delivery
  
  
• Cardiology and Vascular System
  
  
• Pediatrics and Child Health
  
  
• Journal of Reproductive Medicine and Contraception
  
  
• Journal of Respiratory and Lung Disease
  
  
• Journal of Bioinformatics and Biomedicine