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  4. Vol 5, Issue 3, 2025

The Difference of Inflammatory Factors and Oxidative Stress Indexes in Patients with Ischemic Stroke Treated with Bao Yang Huan Wu Decoction Combined with Acupuncture

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DOI: 10.23977/phpm.2025.050308 | Downloads: 2 | Views: 143

Author(s)

Yanbo Diao 1, Ying Guan 1

Affiliation(s)

1 Department of Neurology, First People's Hospital, Heihe, Heilongjiang, 164300, China

Corresponding Author

Yanbo Diao

ABSTRACT

This study aimed to investigate the effects of Buyang Huanwu Decoction combined with acupuncture on inflammatory factors, oxidative stress indices, and neurological function prognosis in patients with ischemic stroke. A total of 80 patients with ischemic stroke were randomly divided into an experimental group and a control group, with 40 cases in each group. The control group received conventional treatment combined with acupuncture, while the experimental group additionally received Buyang Huanwu Decoction on the basis of the control treatment. The treatment course lasted 4 weeks. Changes in inflammatory factors, oxidative stress indices, and neurological function were compared between the two groups before and after treatment. After 4 weeks of treatment, the levels of TNF-α, IL-6, and hs-CRP in the experimental group were significantly lower than those in the control group (P < 0.001). The levels of SOD and GSH-Px were significantly increased, whereas the level of MDA was markedly decreased in the experimental group compared with the control group (P < 0.001). Moreover, the NIHSS score in the experimental group was significantly lower than that in the control group [(4.9 ± 2.3) vs (6.7 ± 2.5), P = 0.001], and the proportion of patients with a favorable mRS outcome was significantly higher (77.5% vs 52.5%, P < 0.05). Buyang Huanwu Decoction combined with acupuncture can effectively attenuate inflammatory responses and oxidative stress injury, improve neurological function, and enhance clinical prognosis, demonstrating high clinical application value.

KEYWORDS

Buyang Huanwu Decoction; Acupuncture; Ischemic Stroke; Inflammatory Factors

CITE THIS PAPER

Yanbo Diao, Ying Guan, The Difference of Inflammatory Factors and Oxidative Stress Indexes in Patients with Ischemic Stroke Treated with Bao Yang Huan Wu Decoction Combined with Acupuncture. MEDS Public Health and Preventive Medicine (2025) Vol. 5: 51-58. DOI: http://dx.doi.org/10.23977/phpm.2025.050308.

REFERENCES

[1] Sun L. Effects of modified Bu Yang Huan Wu Decoction combined with acupuncture on lower limb motor function in patients with ischemic stroke [J]. Health Advisory, 2025(13):182-184.
[2] Qu Hua. Efficacy of ultrasound combined with low-frequency pulse electric therapy and Buyang Huanwu Decoction in treating hemiplegia patients with ischemic stroke [J]. 2023(24):18-21.
[3] Lin L, Zhang W, Wang C. Clinical efficacy of Buyang Huanwu Decoction combined with dual antiplatelet therapy in ischemic stroke patients and its effect on serum inflammatory factors[J]. World Journal of Integrated Traditional Chinese and Western Medicine, 2022,17(7):1416-1420.
[4] Yu Xinglin, Yang Liping, Duan Xiaohua. Research Progress on Mitochondrial Targeted Therapy of Ischemic Stroke with Traditional Chinese Medicine [J]. Medical Review, 2022,28(23):4694-4700.
[5] Zhou Rongwei, Huang Weibin, Deng Jing. Study on the effect of modified Buyang Huanwu Decoction on neurological function recovery in patients with ischemic stroke of qi deficiency and blood stasis type [J]. Modern Diagnosis and Treatment, 2025,36(4):511-513.

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