Author(s)

Zhongfang Gong ¹, Huanyu Jiang ², Yue Zhang ², Xintong Hu ¹, Jianfeng Bao ³

Affiliation(s)

¹ The First Clinical Medical College of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China
² The Fourth Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
³ Xixi Hospital of Hangzhou, Hangzhou, Zhejiang, China

Corresponding Author

Jianfeng Bao

ABSTRACT

To investigate the clinical efficacy of Qiling Ruangan Prescription combined with antiviral therapy in the management of chronic hepatitis B-related liver fibrosis, this study retrospectively analyzed the medical records of 124 patients admitted to our hospital between December 2020 and December 2022, who were stratified into two groups based on whether they received Qiling Ruangan Prescription treatment. Liver function parameters, four liver fibrosis markers, Aspartate Aminotransferase-to-Platelet Ratio Index (APRI), Liver Stiffness Measurement (LSM), and traditional Chinese medicine (TCM) syndrome scores were compared between the two groups before and after treatment. The results demonstrated that after treatment, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin (TBIL), hyaluronic acid (HA), laminin (LN), and chitinase-3-like protein 1 (CHI3L1) were significantly reduced in both groups (P<0.05), with a more remarkable decrease observed in the treatment group (P<0.05). No statistically significant differences in procollagen III N-terminal peptide (PIIINP) and type IV collagen (CIV) were detected between the two groups either pre- and post-treatment or inter-group (P>0.05). Meanwhile, APRI, LSM, and TCM syndrome scores were significantly improved in both groups (P<0.05), and the therapeutic effect in the treatment group was superior to that in the control group (P<0.05). In conclusion, compared with antiviral monotherapy, Qiling Ruangan Prescription combined with antiviral therapy can more effectively improve liver function, optimize liver fibrosis markers, and alleviate TCM syndrome scores in patients with chronic hepatitis B-related liver fibrosis, exerting a more prominent anti-fibrotic effect.

KEYWORDS

Hepatitis B Liver Fibrosis, Qiling Ruangan Prescription, Antiviral Therapy, Clinical Study

CITE THIS PAPER

Zhongfang Gong, Huanyu Jiang, Yue Zhang, Xintong Hu, Jianfeng Bao, Clinical Study on Qiling Ruangan Prescription Combined with Antiviral Therapy for Chronic Hepatitis B Liver Fibrosis. MEDS Chinese Medicine (2025) Vol. 7: 123-130. DOI: http://dx.doi.org/10.23977/medcm.2025.070316.

REFERENCES

[1] Hernandez-Gea V, Friedman SL. Pathogenesis of liver fibrosis[J]. Annu Rev Pathol, 2011, 6:425-56.
[2] Aydın MM, Akçalı KC. Liver fibrosis[J]. Turk J Gastroenterol, 2018, 29(1):14-21.
[3] Lu L, You H, Xie WF, et al. Consensus on Diagnosis and Treatment of Liver Fibrosis (2019)[J]. Modern Medicine and Health, 2019, 35(18):2928-2938.
[4] Marcellin P, Gane E, Buti M, et al. Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study[J]. Lancet. 2013,381(9865):468-75.
[5] Fattovich G, Bortolotti F, Donato F, et al. Natural history of chronic hepatitis B: special emphasis on disease progression and prognostic factors[J]. J Hepatol. 2008,48(2):335-52.
[6] FUKUI H, SAITO H, UENO Y, et al. Evidence-based clinical practice guidelines for liver cirrhosis 2015[J].J Gastroenterol,2016,51(7):629-650.
[7] DU Wentao, REN Wanlei, HU Doudou, et al. Advances in animal models demonstrating reversibility of liver fibrosis[J]. Chinese Journal of Hepatology (Electronic Edition), 2022, 14(3):18-21.
[8] Lu Lungen, You Hong, Xie Weifen, et al. Consensus on Diagnosis and Treatment of Liver Fibrosis (2019 Edition)[J]. Journal of Clinical Hepatology, 2019, 35(10):2163-2172.
[9] Chinese Foundation for Hepatitis Prevention and Control, Chinese Society of Infectious Diseases, Chinese Medical Association, Chinese Society of Hepatology, Chinese Medical Association, Hepatology Professional Committee of Chinese Research Hospital Association. Expert Consensus on Diagnosis of Hepatic Fibrosis by Transient Elastography (2018 Updated Edition)[J]. Chinese Journal of Hepatology, 2019, 27(3): 182-191.
[10] Liang Zhen, Liu Gangtao, Lan Bozhao, et al. Recent Advances in the Pathogenesis of Hepatitis B-Related Liver Fibrosis [J]. Popular Science and Technology, 2015, 17(10):78-80.
[11] Kisseleva T, Brenner D. Molecular and cellular mechanisms of liver fibrosis and its regression[J]. Nat Rev Gastroenterol Hepatol, 2021, 18(3):151-166.
[12] Zhang Yu. Study on the Improvement of Liver Function-Related Indicators in Patients with Compensated Active Hepatitis B-Related Cirrhosis Treated with Soft Liver Granules Combined with Entecavir [J]. Practical Clinical Medicine of Chinese and Western Medicine Integration, 2021, 21(18): 20-21, 63.
[13] Liang L. Impact of long-term antiviral therapy with Entecavir on renal function in elderly patients with chronic hepatitis B  [J] . China Medical Abstracts (Internal Medicine), 2020, 37(1):16
[14] Li Nannan, Zhang Yufeng, Liu Lingfang. Research Progress on the Mechanism of Anti-Liver Cancer Action of Biejia Jianwan [J]. Jiangsu Journal of Traditional Chinese Medicine, 2023, 55(3):72-76.
[15] Huang Jingjing, Zhong Ruixi, Zhu Ronghuo, et al. Research Progress on Biejia Jianwan from Jin Gui Yao Lue [J]. Journal of Liaoning University of Traditional Chinese Medicine, 2022, 24(4):15-19.

Sponsors, Associates, and Links

---

• MEDS Clinical Medicine
  
  
• Journal of Neurobiology and Genetics
  
  
• Medical Imaging and Nuclear Medicine
  
  
• Bacterial Genetics and Ecology
  
  
• Transactions on Cancer
  
  
• Journal of Biophysics and Ecology
  
  
• Journal of Animal Science and Veterinary
  
  
• Academic Journal of Biochemistry and Molecular Biology
  
  
• Transactions on Cell and Developmental Biology
  
  
• Rehabilitation Engineering & Assistive Technology
  
  
• Orthopaedics and Sports Medicine
  
  
• Hematology and Stem Cell
  
  
• Journal of Intelligent Informatics and Biomedical Engineering
  
  
• MEDS Basic Medicine
  
  
• MEDS Stomatology
  
  
• MEDS Public Health and Preventive Medicine
  
  
• Journal of Enzyme Engineering
  
  
• Advances in Industrial Pharmacy and Pharmaceutical Sciences
  
  
• Bacteriology and Microbiology
  
  
• Advances in Physiology and Pathophysiology
  
  
• Journal of Vision and Ophthalmology
  
  
• Frontiers of Obstetrics and Gynecology
  
  
• Digestive Disease and Diabetes
  
  
• Advances in Immunology and Vaccines
  
  
• Nanomedicine and Drug Delivery
  
  
• Cardiology and Vascular System
  
  
• Pediatrics and Child Health
  
  
• Journal of Reproductive Medicine and Contraception
  
  
• Journal of Respiratory and Lung Disease
  
  
• Journal of Bioinformatics and Biomedicine