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  4. Vol 5, Issue 3, 2025

Association of Metabolic Disorders with Thyroid Nodules among Teachers in Puyang County

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DOI: 10.23977/phpm.2025.050304 | Downloads: 1 | Views: 120

Author(s)

Zhenxia Liu 1,2, Yating Li 1, Qian Zhang 1, Guofu Zhang 1

Affiliation(s)

1 School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, China
2 Puyang County People's Hospital, Puyang County, Henan Province, China

Corresponding Author

Guofu Zhang

ABSTRACT

Teachers may carry a substantial burden of thyroid nodules (TN), but the contribution of metabolic diseases and related indicators remains unclear. We analyzed health check-up data from 3,029 in-service teachers to quantify the associations between metabolic diseases/indicators and TN and to characterize dose–response relationships. Multivariable binary logistic regression assessed the associations, and restricted cubic spline (RCS) models characterized nonlinearity. Overall, 1,575 teachers had TN, yielding an age-standardized prevalence of 35.7%. Compared with those without TN, the TN group included higher proportions of women, older individuals, and those with overweight/obesity and hypertension (all P<0.05), and showed higher BMI and systolic blood pressure but lower serum uric acid (SUA) levels (all P<0.05); the prevalence of hyperuricemia (HUA) was lower in the TN group. In multivariable analyses, hypertension, overweight/obesity, female sex, and older age were positively associated with TN. RCS analysis demonstrated a nonlinear dose–response between SUA and TN, with an inverse association at SUA ≤356.16 μmol/L and a positive association at SUA >356.16 μmol/L. TN appears relatively common among teachers; female sex and advancing age are independent risk factors, overweight/obesity and hypertension are positively associated with TN, and SUA shows a threshold-like nonlinear relationship.

KEYWORDS

Thyroid Nodule, Metabolic Disorders, Metabolic Indicator, Teacher

CITE THIS PAPER

Zhenxia Liu, Yating Li, Qian Zhang, Guofu Zhang, Association of Metabolic Disorders with Thyroid Nodules among Teachers in Puyang County. MEDS Public Health and Preventive Medicine (2025) Vol. 5: 20-26. DOI: http://dx.doi.org/10.23977/phpm.2025.050304.

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