Author(s)

Qian Zhang ¹, Xuemeng Zhang ¹, Ting Shi ¹

Affiliation(s)

¹ Department of Pharmacy, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China

Corresponding Author

Qian Zhang

ABSTRACT

To analyze the pharmaco-epidemiological characteristics of adverse drug reaction (ADR) reports related to the Department of Cardiology submitted by Nanjing First Hospital from 2020 to 2024, and to provide a reference for future clinical ADR prevention and management. ADR reports were collected through voluntary reporting by healthcare professionals, retrospective review, and case note screening based on a trigger tool. A total of 226 ADR reports from the Department of Cardiology, submitted between January 2020 and December 2024, were selected as the analysis data. Relevant epidemiological data were gathered, and the Naranjo Adverse Drug Reaction Probability Scale was used to assess the causality of the ADRs. Among the patients in the ADR reports, the mean age was 64.42 ± 12.86 years, comprising 116 males and 110 females; over 60% of the cases were aged over 60 years. Analysis of the administration routes showed that oral dosage forms accounted for 60.2%. Regarding the involved drug types, from 2020 to 2024, ADR reports for intravenous preparations decreased significantly, and reports for adjunctive medications also saw a substantial reduction, while reports for oral dosage forms gradually increased. This suggests that our hospital has achieved certain results in controlling the proportion of intravenous infusions in inpatients, indicating a trend towards more rational clinical drug use. During 2020–2024, contrast agents consistently ranked first in the number of ADR reports in our hospital. In the causality assessment of ADRs, 3 cases (1.3%) were deemed 'definite', 24 cases (10.6%) 'probable', 125 cases (55.3%) 'possible', and 74 cases (32.7%) 'doubtful'. Targeted analysis and preventive management of ADRs related to cardiovascular drugs help enhance the understanding of these medications, avoid the occurrence of ADRs, improve the management of cardiovascular drug therapy, and ensure patient medication safety.

KEYWORDS

Cardiovascular, Adverse Drug Reactions (ADR), Rational Drug Use

CITE THIS PAPER

Qian Zhang, Xuemeng Zhang, Ting Shi, A Retrospective Analysis of Adverse Drug Reaction Reports from the Cardiology Department (2020-2024). Social Medicine and Health Management (2025) Vol. 6: 15-22. DOI: http://dx.doi.org/10.23977/socmhm.2025.060203.

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