Author(s)

Taizhen Li ¹

Affiliation(s)

¹ Jinan Foreign Language School, Jinan, Shandong Province, China

Corresponding Author

Taizhen Li

ABSTRACT

This study focuses on oncogene-driven mechanisms in gastric cancer, employing a murine gastric cancer model to investigate the molecular processes underlying tumor initiation and progression. By comparing gene expression profiles between normal and cancerous tissues, key genes will be identified and their roles in gastric cancer advancement, as well as their associated regulatory networks, will be elucidated. Furthermore, gene-editing technologies will be utilized to functionally validate candidate oncogenes and determine their specific contributions to tumorigenesis. Ultimately, this research indicates that the activation of mechanism of PI3K/Akt pathway-related genes can increase gastric carcinogenesis.

KEYWORDS

Gastric Cancer, Molecular Signal Mechanism, Oncogene, Mouse Model, Gene Expression

CITE THIS PAPER

Taizhen Li, Upregulation of MAPK Pathway Genes: A Potential Driver of Gastric Carcinogenesis. Transactions on Cancer (2025) Vol. 6: 44-49. DOI: http://dx.doi.org/10.23977/tranc.2025.060107.

REFERENCES

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[3] Zhou, X., Guo, Z., Pan, Y. et al. PRSS23-eIF4E-c-Myc axis promotes gastric tumorigenesis and progression. Oncogene 44, 1167–1181 (2025). https://doi.org/10.1038/s41388-025-03294-3
[4] Mulè, Patrizia et al. "WNT Oncogenic Transcription Requires MYC Suppression of Lysosomal Activity and EPCAM Stabilization in Gastric Tumors." Gastroenterology vol. 167,5 (2024): 903-918. doi:10.1053/j.gastro.2024.06.029
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[6] Park Y, Shin YK, Kim J, et al. Genomic landscape of gastric carcinoma. Cancer J, 2016, 22(4): 231-238.
[7] Guan, Xiaoqing et al. "Dual inhibition of MYC and SLC39A10 by a novel natural product STAT3 inhibitor derived from Chaetomium globosum suppresses tumor growth and metastasis in gastric cancer." Pharmacological research vol. 189 (2023): 106703. doi:10.1016/j.phrs.2023.106703
[8] Liao X, Qian X, Zhang Z, et al. ARV-825 Demonstrates Antitumor Activity in Gastric Cancer via MYC-Targets and G2M-Checkpoint Signaling Pathways. Front Oncol. 2021; 11: 753119. Published 2021 Oct 18. doi: 10.3389/fonc. 2021. 753119

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