Author(s)

Kevin Yu ¹, Qun Liu ¹, Yuan Wang ¹

Affiliation(s)

¹ Novapath Medical Device Technology (Yantai) Co., Ltd, Yantai, China

Corresponding Author

Yuan Wang

ABSTRACT

Diabetes mellitus (DM) affects over 537 million adults worldwide and is associated with a wide range of complications, among which chronic diabetic wounds—particularly diabetic foot ulcers (DFUs)—pose a serious clinical challenge. These wounds are notoriously resistant to standard therapies due to persistent hyperglycemia, impaired cellular function, chronic inflammation, and defective tissue remodeling. This study investigates the therapeutic potential of human mesenchymal stem cell–derived exosomes (MSC-Exos) for promoting wound healing in a diabetic mouse model, aiming to provide a cell-free, regenerative treatment alternative for chronic diabetic wounds. Full-thickness circular skin wounds were created on the dorsal surface, and mice were treated with MSC-Exos, recombinant human epidermal growth factor (rhEGF), or a negative control. MSC-Exos treatment resulted in significantly faster wound closure, averaging 22 days, compared to 27–30 days in the rhEGF group and negative control group. Histological analysis demonstrated reduced inflammation and more complete skin regeneration, including the development of hair follicles and sebaceous glands. These findings indicate that MSC-derived exosomes effectively enhance diabetic wound healing and offer potential as a novel therapy for chronic wounds.

KEYWORDS

Diabetes Mellitus, Diabetic Foot Ulcers, Human Mesenchymal Stem Cell, Exosomes

CITE THIS PAPER

Kevin Yu, Qun Liu, Yuan Wang, Therapeutic Effects of Human Mesenchymal Stem Cell–Derived Exosomes on Wound Healing in a Diabetic Mouse Model. MEDS Clinical Medicine (2025) Vol. 6: 76-84. DOI: http://dx.doi.org/10.23977/medsc.2025.060414.

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