Author(s)

Yuao Hu ¹, Mengyao Wang ¹, Yangyang Jin ¹, Mengyuan Zeng ¹

Affiliation(s)

¹ College of Food Science and Technology, Hunan Agricultural University, Changsha, Hunan, 410128, China

Corresponding Author

Yuao Hu

ABSTRACT

Breast milk has long been recognized as the gold standard for designing infant formulas. Among them, oligosaccharides are the third most important solid component in breast milk and a new class of prebiotics. Among the oligosaccharides, 2'-Fucose (2'-FL) has attracted much attention for its important physiological functions. Numerous studies have confirmed that 2'-FL regulates the infant gut microbiota, inhibits pathogen adhesion, modulates immune responses, supports brain and neural development, and reduces inflammation. This review briefly describes the current synthesis methods of 2'-FL and provides insights into its mechanism of action in regulating the intestinal flora. By mimicking the natural functions of breast milk, 2'-FL has the potential to enhance the quality of infant formulas. Deepening the understanding of its physiological roles and interactions could lay the foundation for its wider application in infant nutrition. The present study provides a theoretical framework for utilizing 2'-FL to promote infant health and development.

KEYWORDS

2'-Fucose-based lactose; synthetic method; intestinal flora regulatory mechanism

CITE THIS PAPER

Yuao Hu, Mengyao Wang, Yangyang Jin, Mengyuan Zeng, Synthesis of 2'-fucose-based lactose and analysis of the mechanisms regulating intestinal flora. Advances in Food Science and Human Nutrition (2025) Vol.7: 46-53. DOI: http://dx.doi.org/10.23977/afshn.2025.070107.

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