Author(s)

Yiyang Li ¹, Meichen Liu ¹, Meng Zhang ¹, Yang Yu ¹, Yankui Shi ¹

Affiliation(s)

¹ Laboratory Department, Affiliated Hospital of Hebei University, Baoding, Hebei, 071000, China

Corresponding Author

Meichen Liu

ABSTRACT

Alzheimer's Disease (AD) is the most common cause of dementia in the elderly, placing a significant burden on society and families. Early and accurate diagnosis is crucial for slowing disease progression, improving patients' quality of life, and reducing the burden on caregivers. Blood biomarker testing, as an emerging diagnostic method, offers non-invasive, convenient, and efficient advantages. This article reviews the types of blood biomarkers, their clinical significance, and the value of combined testing in the early diagnosis and clinical application of Alzheimer's Disease, while also discussing existing challenges and future directions for development.

KEYWORDS

Alzheimer's Disease; Blood Biomarkers; Combined Detection; Early Diagnosis; Clinical Application

CITE THIS PAPER

Yiyang Li, Meichen Liu, Meng Zhang, Yang Yu, Yankui Shi, The Value of Combined Detection of Blood Biomarkers in Early Diagnosis and Clinical Application of Alzheimer's Disease. MEDS Basic Medicine (2025) Vol. 3: 123-126. DOI: http://dx.doi.org/10.23977/medbm.2025.030118.

REFERENCES

[1] Wang Gang, Qi Jinlei, Liu Xinya, et al. China Alzheimer's Disease Report 2024 [J]. Diagnostic Theory and Practice, 2024, 23(03):219-256.
[2] Chen Qinghua, Zhang Fengqiang, Li Lixin, et al. Research progress on the pathogenesis and diagnostic techniques of Alzheimer's disease [J]. Chinese Journal of Geriatric Cardiovascular and Cerebrovascular Diseases, 2018, 20(01):108-110.
[3] Li Yawen, Zhang Ruifeng, Guo Lin, et al. Research Progress on the Role of Protein Biomarkers in Early Alzheimer's Disease [J]. Chinese Journal of Gerontology, 2025,45(05):1266-1272.
[4] Sebastian Palmqvist, Shorena Janelidze, Yakeel T Quiroz, et al  .Discriminative Accuracy of Plasma Phospho- tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders[J]. 2020 Aug 25;324(8):772-781. doi:10.1001/jama. 2020. 12134.

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