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  4. Vol 5, Issue 2, 2025

Study on the Evaluation of Coagulation Characteristics in Patients with Gastrointestinal Malignancies by Thrombotic Molecular Markers

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DOI: 10.23977/phpm.2025.050212 | Downloads: 5 | Views: 137

Author(s)

Ya'nan Meng 1, Chengbi Tong 1, Yankui Shi 1, Ji Qi 1

Affiliation(s)

1 Clinical Laboratory, Affiliated Hospital of Hebei University, Hebei, Baoding, 071000, China

Corresponding Author

Ji Qi

ABSTRACT

This study examines the coagulation function characteristics of patients with gastrointestinal malignancies. By comparing the levels of coagulation molecular markers in 215 patients with gastrointestinal malignancies (the case group) and 1 16 healthy controls, it was found that the levels of thrombin-antithrombin complex (TAT) and plasmin-α2-fibrin inhibitor complex (PIC) were significantly elevated in the case group (P<0.001). The t-PAIC level in gastric cancer patients differed from that in colorectal cancer patients (P<0.05), with higher levels in colorectal cancer patients compared to gastric cancer patients. There was no significant difference in thrombotic molecular markers across different tumor stages. The risk score for venous thromboembolism (VTE) increased, and the TM showed a gradient increase. This suggests that coagulation abnormalities may occur early in gastrointestinal malignancies, and as the risk of VTE increases, there is significant endothelial damage, with coagulation molecular marker levels being associated with tumor type and VTE risk.

KEYWORDS

Gastrointestinal Malignancy; Coagulation Molecular Markers; Coagulation Function; Venous Thromboembolism; Tumor Staging

CITE THIS PAPER

Ya'nan Meng, Chengbi Tong, Yankui Shi, Ji Qi, Study on the Evaluation of Coagulation Characteristics in Patients with Gastrointestinal Malignancies by Thrombotic Molecular Markers. MEDS Public Health and Preventive Medicine (2025) Vol. 5: 85-88. DOI: http://dx.doi.org/10.23977/phpm.2025.050212.

REFERENCES

[1] Fan Jian, Zhao Jiayi, Zhou Cihang, et al. Progress in the study of venous thromboembolism associated with malignant tumors [J].International Respiratory Journal, 2021 ,41 (20):1590-1596.
[2] Zheng Yangyang, Yan Hairun, Li Qi, et al. Clinical evaluation of thrombotic molecular markers in patients with malignant tumors [J].Chinese Journal of Laboratory Medicine, 2020,43(01):78-84.
[3] Liu Li, Cao Peijie, Dai Huaijie, et al. Clinical analysis of coagulation function changes in patients with gastrointestinal malignancy [J].Lingnan Journal of Emergency Medicine, 2021,26(1): 80-82 .
[4] Chen Zeran, Zong Yuru, Chen Hanqing.Research progress on molecular mechanism and clinical treatment of liver metastasis in colorectal cancer [J].Guangzhou medicine, 2025,56(3):288-299
[5] Ji Hongliang, Yan Benzun, Yang Zhengliang, et al. Research progress on detection of thrombus and hemostatic molecular markers in thrombotic diseases [J].International Journal of Laboratory Medicine, 2017,38 (17):2434-2436.

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