Author(s)

Qiang Wang ¹, Fenfen Zhang ¹, Zhendong Guo ¹, Yibo Xue ², Min Guo ¹, Jianshe Yang ¹

Affiliation(s)

¹ Gansu Medical College, Pingliang, 744000, Gansu, China
² Pingliang Rehabilitation Center Hospital, Pingliang, 744000, Gansu, China

Corresponding Author

Qiang Wang

ABSTRACT

As a highly prevalent malignant tumor worldwide, the development of therapeutic agents for colorectal cancer has been a hot spot of medical research. Genistein, as a natural isoflavone compound, has attracted much attention in recent years for its remarkable anti-tumor activity. Studies have shown that genistein can regulate the proliferation, apoptosis and metastasis of colorectal cancer cells through multi-targets and multi-pathways, demonstrating a unique molecular mechanism of action. In-depth analysis of the molecular mechanism of genistein against colorectal cancer will not only help to elucidate the material basis of its efficacy, but also provide a theoretical basis for the design of new targeted drugs, which is of great scientific value and clinical translation significance.

KEYWORDS

Genistein; Anti-Colorectal Cancer; Molecular Mechanism; Progress

CITE THIS PAPER

Qiang Wang, Fenfen Zhang, Zhendong Guo, Yibo Xue, Min Guo, Jianshe Yang, Progress of the Molecular Mechanism of Genistein against Colorectal Cancer. MEDS Clinical Medicine (2025) Vol. 6: 15-19. DOI: http://dx.doi.org/10.23977/medsc.2025.060303.

REFERENCES

[1] Qiu Yuan Lignin induces ferroptosis in colorectal cancer cells through the FoxO3/SLC7A11/GPX4 signaling pathway [D]. University of South China, 2024.
[2] Qiu Yuan, Mo Zhongcheng, Chen Yanhua, Lu Hengzhe, Yu Zongchao, Liu Yin, Liu Longfei Research progress on the molecular mechanism of anti colorectal cancer effect of genistein [J]. Chemistry of Life, 2023, 43 (11): 1750-1757.
[3] Liao Lanqing Inhibition of Growth and Mechanism of HCT116 Colon Cancer Cells by Dye Lignin Derivatives [D]. University of South China, 2020.
[4] Long Xiaokang Synthesis, anti-tumor activity, and interaction with bovine serum albumin of lignin derivatives [D]. University of South China, 2019.
[5] Song Shumin The preventive effect and mechanism of genistein on mouse colon cancer [D]. Tianjin University of Science and Technology, 2018.

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