Author(s)

Zihang Shang ¹, Jiaying Liao ¹, Bowei Jiang ¹, Shuqiu Zhang ², Oufei Huang ³, Song Nong ¹

Affiliation(s)

¹ Right Jiang National Medical College's Creativity Center, Baise City, Guangxi, China
² Guangxi Cloud Ball Biotechnology Co. Ltd Research Institute, Baise City, Guangxi, China
³ Guangxi Baise Qingxing Technology Co. Ltd Research Center, Baise City, Guangxi, China

Corresponding Author

Shuqiu Zhang

ABSTRACT

This study explored the link between aluminum (Al) toxicity and beta-amyloid pathology in 52 SPF mice divided into control (saline), low- (2 mg/kg), medium- (4 mg/kg), and high-dose (8 mg/kg) maltol aluminum groups. After 60 days of intraperitoneal injections, Y-maze tests revealed significant learning and memory impairments in medium/high-dose groups (P<0.05). Serum analysis showed elevated TC, TP, and ALT but reduced BUN and Hb in Al-exposed groups (P<0.05). Brain tissue analysis indicated higher Al³⁺ levels in all treated groups (P<0.05), with reduced acetylcholinesterase (AchE) activity in medium/high doses (P<0.05). BACE1 protein (a key enzyme in amyloid production) increased significantly in the high-dose group (P<0.05). Glutathione peroxidase (GSH-PX) levels varied, with serum GSH-PX elevated in the medium-dose group (P<0.05) but brain GSH-PX reduced in medium and elevated in high doses (P<0.05). Aluminum exposure may promote beta-amyloid generation via BACE1 upregulation, impairing cognitive function, supporting a potential mechanistic link between Al toxicity and Alzheimer's-like pathology. 

KEYWORDS

Aluminum Toxicity; Beta-Amyloid; Memory; Learning

CITE THIS PAPER

Zihang Shang, Jiaying Liao, Bowei Jiang, Shuqiu Zhang, Oufei Huang, Song Nong, Comparison and Exploration of Aluminum Toxicity and β-Amyloid Protein Theories. MEDS Clinical Medicine (2025) Vol. 6: 158-164. DOI: http://dx.doi.org/10.23977/medsc.2025.060220.

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