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Study on the Pathogenesis of Streptozocin (STZ)-Induced Type 2 Senile Diabetes in Mice and the Comparative Therapeutic Effects of Guangxi Sweet Tea and Shutangbao

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DOI: 10.23977/medbm.2025.030112 | Downloads: 7 | Views: 233

Author(s)

Yongfu Tang 1, Yili Ma 1, Dongling Cen 1, Bowei Jiang 1, Yongqiu Qiu 1, Duorong Wang 1, Jiajun Guo 1, Qunfang Zhang 1, Linfeng Zhong 1, Shuqiu Zhang 2, Qijun Long 3,4

Affiliation(s)

1 Department of Clinical Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, China
2 Research Center, Guangxi Baise Qingxing Technology Co., Ltd., Baise, Guangxi, 533000, China
3 College of Humanities and Management, Youjiang Medical University for Nationalities, Baise, 533000, Guangxi, China
4 College of Innovation and Entrepreneurship, Youjiang Medical University for Nationalities, Baise, 533000, Guangxi, China

Corresponding Author

Qijun Long

ABSTRACT

This study investigated the pathogenesis and comparative therapeutic effects of Guangxi sweet tea versus Shutangbao in streptozotocin (STZ)-induced type 2 senile diabetic mice, and their effects on Alzheimer's disease. Mice were randomized into four groups: model group, treatment group 1, treatment group 2, and control group. The control group received intraperitoneal injection of 0.3 ml saline for 30 days, followed by 0.3 ml distilled water gavage for another 30 days. The other groups were modeled with STZ combined with aluminum maltolate: 0.3 ml/d intraperitoneal aluminum maltolate for 30 days, then 0.3 ml STZ daily for 5 days. From day 31, treatment groups received 0.3 ml/d Guangxi sweet tea or Shutangbao by gavage for 30 days. Blood glucose levels and learning-memory ability (Y-maze water labyrinth) were measured.Results showed: Model, treatment 1, and 2 groups had higher blood glucose than control group at day 5 post-modeling (P < 0.01). Brain β-secretase activity was higher in the model group (P < 0.05) but lower in treatment groups (P < 0.01, P < 0.05) compared to control group. Treatment groups needed fewer trials in the Y-maze test than the model group (P < 0.01)[1]. Successful modeling was confirmed by increased blood glucose and decreased α-secretase activity. Post-treatment, both groups showed reduced β-secretase activity, improved memory, and treatment 1 showed decreased blood glucose.

KEYWORDS

Streptozotocin; Type 2 Diabetes Mellitus; Blood Glucose; Aluminum Maltol; Learning and Memory Abilities

CITE THIS PAPER

Yongfu Tang, Yili Ma, Dongling Cen, Bowei Jiang, Yongqiu Qiu, Duorong Wang, Jiajun Guo, Qunfang Zhang, Linfeng Zhong, Shuqiu Zhang, Qijun Long, Study on the Pathogenesis of Streptozocin (STZ)-Induced Type 2 Senile Diabetes in Mice and the Comparative Therapeutic Effects of Guangxi Sweet Tea and Shutangbao. MEDS Basic Medicine (2025) Vol. 3: 78-84. DOI: http://dx.doi.org/10.23977/medbm.2025.030112.

REFERENCES

[1] Zhang Shuqiu, Huang Qiuyan, Li Chaogan, et al. Improvement effect of zinc and Haierfu oral liquid on memory impairment in mice caused by lead poisoning measured by Y-type water maze[J]. Chinese Journal of Medical Metallurgy Industry, 2006, (05): 546-548.
[2] Gao Xiaojuan. Alzheimer's disease: Understanding senile dementia [N]. Shanxi Science and Technology News, 2024-05-30(A03).
[3] Nisha Nigil Haroon, Peter C. Austin, Baiju R. Shah, Jianbao Wu, Sudeep S. Gill, Gillian L. Booth; Risk of Dementia in Seniors With Newly Diagnosed Diabetes: A Population-Based Study. Diabetes Care 1 October, 2015, 38 (10): 1868–1875.
[4] Yang Rongrong. The relationship between type 2 diabetes, cerebrovascular disease and the risk of dementia [D]. Tianjin Medical University, 2020. DOI:10.27366/d.cnki.gtyku.2020.000015.
[5] Xiao Zengping, Ji Aiguo. Research progress on the pathogenesis and treatment of Alzheimer's disease [J]. Chinese Journal of Gerontology, 2008, (01): 95-97.
[6] Zhang Lei, Fan Zhanfang, Zhang Zuopeng, Cheng Maosheng, Liu Yang. Research progress on the pathogenesis of Alzheimer's disease and related therapeutic drugs [J]. Chinese Journal of Medicinal Chemistry, 2021, 31 (06): 438-446+469.
[7] Li Ying, Leng Jinhong. Research progress on the pathogenesis of painful diabetic peripheral neuropathy [J]. Journal of Liaoning University of Traditional Chinese Medicine, 2017, 19(11): 117-121. DOI:10.13194/j.issn. 1673-842x.2017.11.034.
[8] Zhang Zheng, Zhang Zhaohui. Research progress on the correlation between Alzheimer's disease and type 2 diabetes [J]. Stroke and Nervous Diseases, 2018, 25(01): 112-117.
[9] He Zhijun, Chen Jierui, Xue Hua, et al. The comorbidity mechanism of Alzheimer's disease and type 2 diabetes and the role of selenium and vanadium [J]. Chinese Bulletin of Life Sciences, 2020, 32(06): 597-605. DOI: 10.13376/j. cbls/2020074. 
[10] Yu Zhen, Wang Kai, Xu Jiachun, Sun Weiming, Zhang Linlin. Progress in the prevention and treatment of Alzheimer's disease by traditional Chinese medicine based on the mechanism of Aβ generation and aggregation [J]. Chinese Journal of Gerontology, 2022, 42(15): 3858-3862.

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