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  4. Vol 6, Issue 2, 2025

Prognosis of Total Occlusion of Culprit Artery in Acute Non-ST Elevation Myocardial Infarction for Different Follow-Ups: A Systematic Review and Meta-Analysis

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DOI: 10.23977/medsc.2025.060213 | Downloads: 12 | Views: 357

Author(s)

Tingting Chen 1, Hua Yang 1, Yue Shen 1, Ting Wang 1, Xiang Li 1, Ying Yang 2

Affiliation(s)

1 School of Clinical Medicine, Dali University, Dali, Yunnan, China
2 Department of Cardiology, The First Affiliated Hospital of Dali University, Dali, Yunnan, China

Corresponding Author

Ying Yang

ABSTRACT

This systematic review aims to analyze the clinical prognosis of NSTEMI patients with total occlusion of culprit artery (TOCA) and non-TOCA across different follow-up periods. The literature search up to March 26, 2024, identified 11 observational studies. TOCA patients had significantly higher in-hospital mortality (OR = 2.43, 95% CI [1.73–3.40]; p < 0.00001). TOCA also had higher MACE rates in all follow-up periods: in-hospital (OR = 1.58, 95% CI [1.11–2.24]; p = 0.01), short-term (OR = 1.86, 95% CI [1.57–2.20]; I2 = 0; P < 0.00001), and long-term (OR = 1.55, 95% CI [1.05–2.28]; I2 = 74; p = 0.03). Additionally, TOCA was linked to higher recurrent MI rates in short-term (OR = 1.53, 95% CI [1.13–2.09]; I2 = 25; p = 0.007) and long-term follow-up (OR = 1.67, 95% CI [1.07–2.60]; I2 = 41; p = 0.02). Despite worse prognosis for TOCA patients, further randomized controlled trials are needed for definitive conclusions.

KEYWORDS

Acute Non-ST Elevation Myocardial Infarction, Total Occlusion of Culprit Artery, Prognosis, Different Follow-Ups, Meta-Analysis

CITE THIS PAPER

Tingting Chen, Hua Yang, Yue Shen, Ting Wang, Xiang Li, Ying Yang, Prognosis of Total Occlusion of Culprit Artery in Acute Non-ST Elevation Myocardial Infarction for Different Follow-Ups: A Systematic Review and Meta-Analysis. MEDS Clinical Medicine (2025) Vol. 6: 87-96. DOI: http://dx.doi.org/10.23977/medsc.2025.060213.

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