Author(s)

Qian Guo ¹, Xiaohua Wu ¹, Chan Zhao ²

Affiliation(s)

¹ First Clinical School of Medicine, Shaanxi University of Chinese Medicine, Xianyang, China
² Department of Dermatology, Baoji Hospital of Traditional Chinese Medicine Affiliated with Shaanxi University of Chinese Medicine, Baoji, China

Corresponding Author

ABSTRACT

Rosai-Dofman disease, also known as sinusoidal histiocytosis with giant lymphadenopathy, was first reported by Rosai and Dorfman in 1969. It is a rare histiocytic proliferative disease with typical .clinical features of enlarged cervical lymph nodes, fever, leukocytosis, increased sedimentation rate, anemia and hypogammaglobulinemia. Which occurs mainly in lymph nodes, and 43% of the patients have both Involvement of extranodal tissues, of which the skin is the most common site of involvement accounts for about 11%.other extranodal tissues include soft tissues, respiratory tract, genitourinary tract, oral cavity, gastrointestinal tract, orbits, testes, rarely involves the central nervous system, and only skin damage accounts for about 3%. When occurs in the skin alone and does not involve lymph nodes, it is known as cutaneous sinusoidal dyshidrotic dyshidrotic dysplasia (CRDD). CRDD usually affects middle-aged and older adults, with a female predominance, and is reported mainly in patients of Asian and Caucasian ethnicity.

KEYWORDS

CITE THIS PAPER

Qian Guo, Xiaohua Wu, Chan Zhao. Cutaneous Rosai-Dorfman Disease. MEDS Clinical Medicine (2025) Vol. 6: 86-92. DOI: http://dx.doi.org/10.23977/medsc.2025.060113.

REFERENCES

[1] Rosai J, Dorfman RF. Sinus histioc ytosis with massive lymphadenopathy. A newly recognized benign clinicopath -ological entityJ].Arch Pathol, 1969. 87 (1):63-70.
[2] Zhang F, Liu WT, Yu B, Nan HL. A case of cutaneous sinus histiocytosis with literature review[J]. Chinese Journal of Leprosy and Dermatology, 2020, 36(01):35-37.
[3] Montazer F, Farahani S, Shaka Z, Aryanian Z, Goodarzi A. A pure cutaneous Rosai-Dorfman disease: case report and a review of the literature. Caspian J Intern Med. 2022 Fall; 13(4):818-826. 
[4] Gudong, Wu Tieqiang. A case of cutaneous Rosai-Dorfman disease[J]. Journal of Dermatologic and Venereal Diagnosis and Treatment, 2019, 26(02):97-100.
[5] Chen Yahui, Chen Siyuan. Clinical and histopathologic analysis of 15 cases of cutaneous Rosai-Dorfman disease [J]. Journal of Clinical Dermatology, 2023, 52(02):67-70.
[6] Ding Xiaolan, Zhang Jianzhong. Research progress of cutaneous sinus histiocytosis with giant lymphadenopathy[J]. Chinese Journal of Dermatology and Venereology, 2009, 23(11):760-762.
[7] Ahmed A, Crowson N, Magro CM. A comprehensive assessment of cutaneous Rosai-Dorfman disease. Ann Diagn Pathol. 2019 Jun; 40: 166-173.
[8] Zhang YX, Zheng BY, Nie TF. Progress of clinical research on cutaneous Rosai-Dorfman disease[J]. Dermatology and Venereology, 2021, 43(02):181-183.
[9] Kong YY, Kong JC, Shi DR, et al. Cutaneous rosai-dorfman disease: a clinical and histopathologic study of 25 cases in China. American Journal of Surgery Pathol. 2007;31(3):341-350. 
[10] Rizwan MM, Chhabra G, Mishra A, et al. A case of isolated cutaneous Rosai-Dorfman-Syndrome[J]. Gulf J Oncolog, 2013, 1 (14): 87-89. 
[11] WANG Wei, CHEN Xiaodong, PENG Dayun, YANG Lei. Clinicopathologic analysis of seven cases of Rosai-Dorfman disease outside lymph nodes[J]. Journal of Clinical and Experimental Pathology, 2012, 28(04):406-409+414.DOI:10.13315/j.cnki.cjcep.2012.04.005.
[12] Xiang Liping, He Huihua, Yuan Jingping, Liu Lin, Rao J. Clinicopathologic analysis of 13 cases of Rosai-Dorfman disease[J]. Chinese Journal of Histochemistry and Cytochemistry, 2023, 32(01):77-80.
[13] LI Zhen, HAO Yong, YANG Mei, et al. A case of cutaneous plasma cell hyperplasia[J]. Chinese Journal of Leprosy and Dermatology, 2018, 34(10):622-623.
[14] Gudong, Wu Tieqiang. A case of cutaneous Rosai-Dorfman disease[J]. Journal of Dermatologic and Venereal Diagnosis and Treatment, 2019, 26(02):97-100.

Sponsors, Associates, and Links

• Journal of Neurobiology and Genetics
  
  
• Medical Imaging and Nuclear Medicine
  
  
• Bacterial Genetics and Ecology
  
  
• Transactions on Cancer
  
  
• Journal of Biophysics and Ecology
  
  
• Journal of Animal Science and Veterinary
  
  
• Academic Journal of Biochemistry and Molecular Biology
  
  
• Transactions on Cell and Developmental Biology
  
  
• Rehabilitation Engineering & Assistive Technology
  
  
• Orthopaedics and Sports Medicine
  
  
• Hematology and Stem Cell
  
  
• Journal of Intelligent Informatics and Biomedical Engineering
  
  
• MEDS Basic Medicine
  
  
• MEDS Stomatology
  
  
• MEDS Public Health and Preventive Medicine
  
  
• MEDS Chinese Medicine
  
  
• Journal of Enzyme Engineering
  
  
• Advances in Industrial Pharmacy and Pharmaceutical Sciences
  
  
• Bacteriology and Microbiology
  
  
• Advances in Physiology and Pathophysiology
  
  
• Journal of Vision and Ophthalmology
  
  
• Frontiers of Obstetrics and Gynecology
  
  
• Digestive Disease and Diabetes
  
  
• Advances in Immunology and Vaccines
  
  
• Nanomedicine and Drug Delivery
  
  
• Cardiology and Vascular System
  
  
• Pediatrics and Child Health
  
  
• Journal of Reproductive Medicine and Contraception
  
  
• Journal of Respiratory and Lung Disease
  
  
• Journal of Bioinformatics and Biomedicine