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  4. Vol 5, Issue 1, 2025

Clinical Characteristics Analysis of Hemorrhagic Fever with Renal Syndrome in 145 Children of Different Age Groups

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DOI: 10.23977/phpm.2025.050104 | Downloads: 13 | Views: 533

Author(s)

Lu Cao 1, Yufeng Zhang 2, Xiaoyan Wang 2, Kairui Lei 2

Affiliation(s)

1 School of Public, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
2 The 2nd Department of Infectious Diseases, Xi'an Children's Hospital, Xi'an, 710003, China

Corresponding Author

Yufeng Zhang

ABSTRACT

To summarize and analyze the clinical characteristics of Hemorrhagic Fever with Renal Syndrome (HFRS) in children of different age groups, we aim to provide important information for the diagnosis, treatment, and prevention of the disease. Clinical data of 145 pediatric cases of Hemorrhagic Fever with Renal Syndrome (HFRS) from Xi'an Children's Hospital between 2019 and 2021 were collected through a cross-sectional survey. The three-dimensional distribution of HFRS in children was described, and the clinical characteristics and laboratory indicators of HFRS across different age groups were analyzed. Of the 145 children, 105 (72.4%) were males and 40 (27.5%) were females, with a mean age of (9.17±3.69) years. The cases were mainly concentrated in rural and suburban areas (85.5%). It peaked in winter. The main symptoms of 145 children were fever (144 cases, 99.3%), congestion (91 cases, 62.8%), bleeding (89 cases, 61.4%), and abdominal pain (89 cases, 61.4%). The 145 children were divided into four groups according to age: <5 years, 5-9 years, 9-12 years, and >12 years. Some of the typical clinical symptoms such as petechial hemorrhage, hemorrhagic shock, oliguria, orbital pain, and electrolyte disorders were more typical between the ages of 9-12 years than the other age groups (P < 0.05). Some blood indices such as ALT, BUN, PCT, ALB, PLT, Hb, Na, Ca were more typical between 9-12 years of age than other age groups (P < 0.05).The clinical manifestations of Hemorrhagic Fever with Renal Syndrome (HFRS) in children are often atypical, predominantly affecting school-age boys, with peaks in November and December. During high-incidence seasons or in endemic areas, healthcare providers maintain heightened vigilance for children presenting with liver and kidney function abnormalities or electrolyte imbalances, promptly conducting comprehensive relevant tests to avoid missed or misdiagnoses.

KEYWORDS

Children; Infectious Diseases; Hemorrhagic Fever with Renal Syndrome; Epidemiology; Clinical Characteristics

CITE THIS PAPER

Lu Cao, Yufeng Zhang, Xiaoyan Wang, Kairui Lei, Clinical Characteristics Analysis of Hemorrhagic Fever with Renal Syndrome in 145 Children of Different Age Groups. MEDS Public Health and Preventive Medicine (2025) Vol. 5: 17-25. DOI: http://dx.doi.org/10.23977/phpm.2025.050104.

REFERENCES

[1] Ashique S, Sandhu NK, Das S, Haque SN, Koley K. Global Comprehensive Outlook of Hantavirus Contagion on Humans: A Review. Infect Disord Drug Targets. 2022;22(3):12-27
[2] Riquelme R. Hantavirus[C]//Seminars in Respiratory and Critical Care Medicine. Thieme Medical Publishers, Inc.2021,42(06):822-827.
[3] Vaheri A, Henttonen H, Mustonen J. Hantavirus research in Finland: highlights and perspectives[J]. Viruses, 2021,13(8):1452.
[4] Jiang H, Du H, Wang LM, Wang PZ, Bai XF. Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture. Front Cell Infect Microbiol. 2016 Feb 3;6:1.
[5] Diagnostic criteria for epidemic hemorrhagic fever: WS278-2008 [S]. Beijing: People's Health Publishing House, 2008.
[6] Chinese Society of Preventive Medicine, Infectious Disease Prevention and Control Branch, Chinese Medical Association, Infectious Diseases Branch. Expert consensus on the prevention and control of hemorrhagic fever in renal syndrome[J]. Chinese Journal of Infectious Diseases,2021,39(05):257-265.
[7] ZHAO Qing, PANG Mingfan, FANG Yuansheng, et al. Risk assessment of global infectious disease events in May 2024[J]. Disease Surveillance,2024,39(06):677-680.  
[8] Wu J, Wang DD, Li XL, de Vlas SJ, Yu YQ, Zhu J, Zhang Y, Wang B, Yan L, Fang LQ, Liu YW, Cao WC. Increasing incidence of hemorrhagic fever with renal syndrome could be associated with livestock husbandry in Changchun, northeastern China. BMC Infect Dis. 2014 Jun 3;14:301.
[9] JiangH, ZhengX, WangL, et al. Hantavirus infection: a global zoonotic challenge[J]. Virol Sin, 2017, 32(1): 32-43.
[10] SU Yongjian, LIANG Jinliang, ZHANG Jiawei, et al. Trend analysis of epidemic hemorrhagic fever in China from 2005 to 2021[J]. Zhonghua sanitary insecticide armament,2023,29(06):531-538.
[11]Shaanxi Statistical Bureau. (2019-2022). Shaanxi statistical yearbook 2019-2022.
[12] Deng Xuefei, Du Shanshan, Huang Xiaoxia, et al. Epidemiological characterization of reported cases of renal syndrome hemorrhagic fever in China, 2004-2021[J]. Disease Surveillance,2023,38(01):70-74.
[13] HUANG Changshang,JIANG Hong,BAI Xuefan,Shaanxi Provincial Health Commission,Tangdu Hospital of Air Force Military Medical University. Expert consensus on diagnosis and treatment of hemorrhagic fever of renal syndrome in Shaanxi Province[J]. Shaanxi Medical Journal,2019,48(3):275-288.
[14] MA Chaofeng,YU Pengbo,LI Hengxin,et al. Current status of renal syndrome hemorrhagic fever epidemic and immunization strategy in China[J]. Chinese Journal of Preventive Medicine,2014(12):1039-1042.
[15] ZHENG Zhangqi, LIN Qihan, DU Shanshan, et al. Epidemic status and preventive control of renal syndrome hemorrhagic fever in China[J]. Tropical Diseases and Parasitology,2024,22(03):129-132+139.
[16] Deng Xuefei, Du Shanshan, Huang Xiaoxia, et al. Epidemiological characterization of reported cases of renal syndrome hemorrhagic fever in China, 2004-2021[J]. Disease Surveillance,2023,38(01):70-74.
[17] Dzagurova TK, Tkachenko EA, IshmukhametovAA, et al. Severe hantavirus disease in children[J]. J Clin Virol, 2018,101:66-68.
[18] MA Hongwei, XTJ, MA Yongtao, et al. Clinical characterization of pediatric renal syndrome hemorrhagic fever[J]. Chinese Journal of Contemporary Pediatrics, 2014,16(11): 1091-1095. 
[19] Aslani D, Salehi-Vaziri M, Baniasadi V, Jalali T, Azad-Manjiri S, Mohammadi T, Khakifirouz S, Fazlalipour M. Crimean-Congo hemorrhagic fever among children in Iran. Arch Virol. 2017 Mar;162(3):721-725. 
[20] Katzelnick LC, Gresh L, Halloran ME, Mercado JC, Kuan G, Gordon A, Balmaseda A, Harris E. Antibody-dependent enhancement of severe dengue disease in humans. Science. 2017 Nov 17;358(6365):929-932.
[21] ZHOU Yong, WANG Ying, GUO Zhangyan, et al. Analysis of risk factors associated with hemorrhagic fever in children with renal syndrome[J]. International Journal of Pediatrics,2023,50(9):643-648.
[22] Ahlm C, Settergren B, Gothefors L, Juto P. Nephropathia epidemica (hemorrhagic fever with renal syndrome) in children: clinical characteristics. Pediatr Infect Dis J. 1994 Jan;13(1):45-49. 
[23] Deng HL, Zhang YF, Liu YY, et al. Clinical characteristics of 60 pediatric patients with hemorrhagic fever with renal syndrome and factors influencing the high risk of severe form[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition),2018,12(02):150-154.
[24] JIANG J,CHENG CHUNHONG. Clinical analysis of 72 cases of renal syndrome hemorrhagic fever combined with liver damage[J]. China Practical Medicine,2012,7(12):158-159.
[25] Du H, Li J, Yu HT, Jiang W, Zhang Y, Wang JN, Wang PZ, Bai XF. Early indicators of severity and construction of a risk model for prognosis based upon laboratory parameters in patients with hemorrhagic fever with renal syndrome. Clin Chem Lab Med. 2014 Nov;52(11):1667-1675.  
[26] Huang YH, Zhang L, Ye ZC, et al. CK-MB/CK ratio to identify pseudo-elevations detected by CK-MB activity method in children[J]. Laboratory Medicine,2023,38(6):538-542. 
[27] Jiang H, Du H, Wang LM, Wang PZ, Bai XF. Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture. front Cell Infect Microbiol. 2016 Feb 3;6:1.  
[28] Yang XR, Yan L, Song HE, et al. Epidemiological and clinical characterization of 49 cases of hemorrhagic fever with severe renal syndrome in children[J]. China Pediatric Emergency Medicine,2023,30(7):525-530.

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