Author(s)

Weilin Yang ¹, Siyang Yi ¹, Xianjie Zhang ¹

Affiliation(s)

¹ Department of Anesthesiology, The Deyang People's Hospital, Deyang, Sichuan, 618000, China

Corresponding Author

Xianjie Zhang

ABSTRACT

This study is designed to explore the 50% effective dose (ED50) and 95% effective dose (ED95) of oliceridine combined with remimazolam required for sedation procedures in adult patients undergoing gastroscopy. The improved Dixon sequential method will be adopted in the study, with an initial dose of 15 µg/kg oliceridine combined with 0.3 mg/kg remimazolam, with a gradient dose of 1.5 µg/kg for oliceridine. If the administration of medications do not meet the requirements for gastroscopy procedure and the improved alertness/sedation score is greater than 2 points within 5 minutes after administration, indicating insufficient dose of oliceridine. The oliceridine dose escalation proceeds to the next. Otherwise, descend a gradient. The study will be terminated after seven crossovers. The ED50, ED95 and corresponding 95% confidence intervals (CIs) will be calculated for oliceridine by the probit method.

KEYWORDS

Oliceridine, Sedation, Gastroscopy, Effective dose, Protocol

CITE THIS PAPER

Weilin Yang, Siyang Yi, Xianjie Zhang. Modified Dixon sequential method to determine the effective dose of oliceridine combined with remimazolam besylate for painless gastroscopy: protocol for a clinical trial. MEDS Clinical Medicine (2025) Vol. 6: 37-42. DOI: http://dx.doi.org/10.23977/medsc.2025.060106.

REFERENCES

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