Endoplasmic reticulum stress-related regulatory mechanisms in liver disease

Luyuan Yang; Xiaofeng Wang

doi:10.23977/medbm.2024.020220

Endoplasmic reticulum stress-related regulatory mechanisms in liver disease

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DOI: 10.23977/medbm.2024.020220 | Downloads: 15 | Views: 493

Author(s)

Luyuan Yang ¹, Xiaofeng Wang ²

Affiliation(s)

¹ Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
² Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712000, China

Corresponding Author

Xiaofeng Wang

ABSTRACT

The endoplasmic reticulum plays a key role in protein synthesis, peptide chain folding and processing, post-translational modifications, lipid biosynthesis, calcium storage, and detoxification. When endoplasmic reticulum homeostasis is affected by a variety of physiopathological factors, such as nutritional deficiencies, excessive protein synthesis, hypoxia, abnormal endoplasmic reticulum calcium content, lipid overload, oxidative stress, and infections, unfolded or misfolded proteins can accumulate excessively in the endoplasmic reticulum lumen, which can lead to ERS. In recent years, it has been found that the three types of ERS not only are highly correlated with liver diseases but also suppress apoptosis by regulating related pathways to inhibit apoptosis. In addition, the regulation of these pathways and their associated factors is also closely related to immune system diseases and metabolic diseases. In this paper, we review the important roles of endoplasmic reticulum stress-related mechanisms in liver diseases in recent years, which will provide some ideas and insights for future researchers to carry out related studies.

KEYWORDS

Endoplasmic reticulum; unfolded protein response; liver disease; cellular homeostasis

CITE THIS PAPER

Luyuan Yang, Xiaofeng Wang, Endoplasmic reticulum stress-related regulatory mechanisms in liver disease. MEDS Basic Medicine (2024) Vol. 2: 140-145. DOI: http://dx.doi.org/10.23977/medbm.2024.020220.

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Endoplasmic reticulum stress-related regulatory mechanisms in liver disease

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ABSTRACT

KEYWORDS

CITE THIS PAPER

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