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Investigation on the Specific Pathogenesis of Alzheimer's Disease Model Mice Induced by Subchronic Aluminum Exposure

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DOI: 10.23977/medbm.2024.020215 | Downloads: 18 | Views: 660

Author(s)

Shikang Huang 1, Haimei Huang 1, Jiaguo Liang 1, Qingcui Huang 1, Jiajun Guo 1, Liujiao Huang 1, Zhongjian Su 1, Chaoyuan Yang 1, Wenjin Huang 1, Jie Liang 2

Affiliation(s)

1 Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, China
2 Affiliated Hospital of Youjiang University of Ethnic Medicine, Baise, Guangxi, 533000, China

Corresponding Author

Jie Liang

ABSTRACT

This experiment sought to investigate the pathogenesis of Alzheimer's due to subchronic aluminum exposure by comparing its impact on mouse brain α-, β-, and γ-secretases. Thirty SPF mice were split into a normal group, a medium-dose group (0.30ml aluminum maltol solution per mouse daily), and a high-dose group (0.45ml). They were intraperitoneally injected for 30 days. Utilizing the obvious neurotoxic effect of aluminum maltol [1], different degrees of poisoning were caused by injecting different doses of aluminum maltol, and the memory ability of mice was evaluated using the Y-maze water test[2], The Y-maze water test evaluated memory. Afterward, serum and brain tissue were sampled for biochemical and enzyme assays. Y-maze results showed that higher aluminum exposure led to longer times and distances for mice in water. Group differences post-exposure and within the medium-dose group were significant. TG, TC, TP, and brain protein levels varied among groups. Regarding secretases, β-secretase differed from the normal group (P < 0.01), α-secretase from the high-dose group (P < 0.05), and γ-secretase from the normal group (P < 0.05). In conclusion, aluminum may trigger Alzheimer's via secretase regulation, and γ-secretase's role requires further exploration.

KEYWORDS

Mice, Aluminum Maltol, β-Secretase, α-Secretase, γ-Secretase, Alzheimer's Disease, Pathogenesis

CITE THIS PAPER

Shikang Huang, Haimei Huang, Jiaguo Liang, Qingcui Huang, Jiajun Guo,  Liujiao Huang, Zhongjian Su, Chaoyuan Yang, Wenjin Huang, Jie Liang, Investigation on the Specific Pathogenesis of Alzheimer's Disease Model Mice Induced by Subchronic Aluminum Exposure. MEDS Basic Medicine (2024) Vol. 2: 105-112. DOI: http://dx.doi.org/10.23977/medbm.2024.020215.

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