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  4. Vol 2, Issue 2, 2024

A Review of the Inhibitory Effect of Epigallocatechin Gallate on the Cariogenicity of Streptococcus Mutans

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DOI: 10.23977/medbm.2024.020214 | Downloads: 14 | Views: 618

Author(s)

Sirui Song 1, Yu Cheng 1, Pei Zheng 1

Affiliation(s)

1 School of Stomatology, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, China

Corresponding Author

Pei Zheng

ABSTRACT

Streptococcus mutans (S. mutans) are currently recognized as the most important cariogenic bacteria. Their main cariogenic behaviors include adhesion, acid production and acid resistance, and inducing cariogenic transformation of oral microecology. Streptococcus mutans (S. mutans) colonize the oral cavity by adhering to the oral cavity and forming a biofilm, which produces acid and leads to the demineralization of teeth and the formation of cavities. The cariogenic transformation of oral microecology further promotes the formation of cariogenic biofilm and eventually leads to the occurrence of caries. Epigallocatechin gallate (EGCG) is one of the most abundant and important catechins in green tea. It is generally considered to have good antioxidant, anti-inflammatory and antibacterial properties. In vitro and in vivo studies have shown that EGCG can significantly inhibit the cariogenic ability of S. mutans, suggesting that EGCG has a broad application prospect in caries prevention. In addition to its ability to kill or inhibit S. mutans, EGCG inhibits S. mutans biofilm formation by promoting S. mutans cell aggregation, reducing S. mutans surface hydrophobicity, inhibiting the function of S. mutans surface protein and the formation of extracellular matrix. By inhibiting the activity and synthesis of lactate dehydrogenase and a series of related enzymes of S. mutans, EGCG can inhibit acid production and acid resistance. It can also inhibit cariogenic transformation of oral microecology. This article reviews the related research in recent years.

KEYWORDS

Streptococcus mutans; Epigallocatechin gallate; Biofilm; Dental caries; Oral microecology

CITE THIS PAPER

Sirui Song, Yu Cheng, Pei Zheng, A Review of the Inhibitory Effect of Epigallocatechin Gallate on the Cariogenicity of Streptococcus Mutans. MEDS Basic Medicine (2024) Vol. 2: 96-104. DOI: http://dx.doi.org/10.23977/medbm.2024.020214.

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