Author(s)

Sun Kexin ¹

Affiliation(s)

¹ First Clinical Hospital of Zhejiang University of Traditional Chinese Medicine, Hangzhou City, Zhejiang Province, China

Corresponding Author

Sun Kexin

ABSTRACT

This study investigates the clinical efficacy of modified Huangqi Jianzhong Tang in treating spleen-stomach deficiency cold pattern gastric ulcers, comparing its effects with conventional Western medical treatments. Ninety-six patients diagnosed with this pattern at our hospital from July 2022 to July 2023 were randomly assigned to either the treatment group or the control group, with 48 patients in each. The treatment group received the modified Huangqi Jianzhong Tang, while the control group underwent standard Western medical therapy. The treatment lasted for 8 weeks. Primary outcome measures included Traditional Chinese Medicine (TCM) symptom scores, gastrin levels, serum markers (such as IL-10, TGF-β1, IL-17), and Helicobacter pylori eradication rates. Results indicated that both groups experienced a reduction in TCM symptom scores such as epigastric pain, acid reflux, bloating, and fullness, with the treatment group showing a significantly greater reduction (P<0.05). Reductions in gastrin levels were also more pronounced in the treatment group (P<0.05). Decreases in IL-10, TGF-β1, and IL-17 levels were observed in both groups, with larger decreases in the treatment group (P<0.05). Additionally, the H. pylori eradication rate and the overall clinical effectiveness were significantly higher in the treatment group (x²=4.36, p=0.037 and X2=4.02, p=0.045, respectively). These findings suggest that the modified Huangqi Jianzhong Tang not only effectively alleviates symptoms of spleen-stomach deficiency cold pattern gastric ulcers but also modulates immune responses and promotes gastric function recovery.

KEYWORDS

Spleen-Stomach Deficiency Cold Pattern Gastric Ulcers; Huangqi Jianzhong Tang; Gastrin; Helicobacter pylori Eradication Rate

CITE THIS PAPER

Sun Kexin, Clinical Efficacy of Modified Huangqi Jianzhong Tang in the Treatment of Spleen-Stomach Deficiency Cold Pattern Gastric Ulcers. MEDS Clinical Medicine (2024) Vol. 5: 166-172. DOI: http://dx.doi.org/10.23977/medsc.2024.050422.

REFERENCES

[1] Kamada T, Satoh K, Itoh T, et al. Evidence-based clinical practice guidelines for peptic ulcer disease 2020[J]. Journal of gastroenterology, 2021, 56: 303-322.
[2] Malfertheiner P, Megraud F, Rokkas T, et al. Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report [J]. Gut, 2022, 71(9): 1724-1762.
[3] Huang J Q, Sridhar S, Hunt R H. Role of Helicobacter pylori infection and non-steroidal anti-inflammatory drugs in peptic-ulcer disease: a meta-analysis [J]. The Lancet, 2002, 359(9300): 14-22.
[4] Kuna L, Jakab J, Smolic R, et al. Peptic ulcer disease: a brief review of conventional therapy and herbal treatment options [J]. Journal of clinical medicine, 2019, 8(2): 179.
[5] Lanas A, Chan F K L. Peptic ulcer disease [J]. The Lancet, 2017, 390(10094): 613-624.
[6] Lü Bin, Chen Weichang, Kou Yi, et al. Guidelines for Primary Care of Chronic Gastritis (Practical Version 2019) [J]. Chinese Journal of General Practitioners, 2020, 19(9): 776-782.
[7] Lei M Y. Research progress of traditional Chinese medicine in the prevention and treatment of dyspepsia following spleen stomach weakness [J]. Med Data Min, 2022, 5(1): 5.
[8] Hu J, He T, Liu J, et al. Pharmacological and molecular analysis of the effects of Huangqi Jianzhong decoction on proliferation and apoptosis in GES-1 cells infected with H. pylori [J]. Frontiers in Pharmacology, 2022, 13: 1009705.
[9] Liu Y, Xu W, Wang G H, et al. Material basis research for Huangqi Jianzhong Tang against chronic atrophic gastritis rats through integration of urinary metabonomics and SystemsDock[J]. Journal of ethnopharmacology, 2018, 223: 1-9.
[10] Sun Y, Zhang J, Chen Y. Efficacy and safety of Jianzhong decoction in treating peptic ulcers: a meta-analysis of 58 randomised controlled trials with 5192 patients [J]. BMC complementary and alternative medicine, 2017, 17: 1-16.
[11] Nie B, Luo R, Chen X, et al. Clinical Study on Moxibustion Therapy for Gastric Pain of Deficiency-Cold Type [J]. Journal of Acupuncture and Tuina Science, 2011, 9: 98-100.
[12] Jia L, Qin X, Liu Y. Integrated pharmacokinetics of Huangqi Jianzhong Tang in normal and chronic atrophic gastritis rats [J]. Biomedical Chromatography, 2022, 36(12): e5492.
[13] Wei Y, Ma L X, Yin S J, et al. Huangqi Jianzhong Tang for treatment of chronic gastritis: a systematic review of randomized clinical trials[J]. Evidence‐Based Complementary and Alternative Medicine, 2015, 2015(1): 878164. 

Sponsors, Associates, and Links

---

• Journal of Neurobiology and Genetics
  
  
• Medical Imaging and Nuclear Medicine
  
  
• Bacterial Genetics and Ecology
  
  
• Transactions on Cancer
  
  
• Journal of Biophysics and Ecology
  
  
• Journal of Animal Science and Veterinary
  
  
• Academic Journal of Biochemistry and Molecular Biology
  
  
• Transactions on Cell and Developmental Biology
  
  
• Rehabilitation Engineering & Assistive Technology
  
  
• Orthopaedics and Sports Medicine
  
  
• Hematology and Stem Cell
  
  
• Journal of Intelligent Informatics and Biomedical Engineering
  
  
• MEDS Basic Medicine
  
  
• MEDS Stomatology
  
  
• MEDS Public Health and Preventive Medicine
  
  
• MEDS Chinese Medicine
  
  
• Journal of Enzyme Engineering
  
  
• Advances in Industrial Pharmacy and Pharmaceutical Sciences
  
  
• Bacteriology and Microbiology
  
  
• Advances in Physiology and Pathophysiology
  
  
• Journal of Vision and Ophthalmology
  
  
• Frontiers of Obstetrics and Gynecology
  
  
• Digestive Disease and Diabetes
  
  
• Advances in Immunology and Vaccines
  
  
• Nanomedicine and Drug Delivery
  
  
• Cardiology and Vascular System
  
  
• Pediatrics and Child Health
  
  
• Journal of Reproductive Medicine and Contraception
  
  
• Journal of Respiratory and Lung Disease
  
  
• Journal of Bioinformatics and Biomedicine