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Research on the Clinical Test Value of D-D and Coagulation Indicators in Patients with Hypertension during Pregnancy

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DOI: 10.23977/medbm.2024.020212 | Downloads: 18 | Views: 812

Author(s)

Liang Ming 1, Zhaofan Luo 1

Affiliation(s)

1 The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, 518000, China

Corresponding Author

Zhaofan Luo

ABSTRACT

Coagulation indicators not only change within the bodies of normal pregnant women but are also closely related to various pregnancy-related diseases, such as hypertensive disorders complicating pregnancy (HDCP). HDCP is a common condition during pregnancy, which can be categorized into gestational hypertension (GH) and preeclampsia (PE), among others. In addition to posing risks to both pregnant women and their fetuses around the time of birth, HDCP can have long-term effects on the mother. Studies suggest that patients with HDCP have abnormal coagulation function, primarily due to the production of various active factors resulting from placental dysfunction in these patients. Once these active factors enter maternal circulation, they lead to small vessel spasms, endothelial cell damage, and activated coagulation responses, causing HDCP patients to experience a pathological hypercoagulable state. Therefore, analyzing coagulation indicators and D-dimer (D-D) parameters in HDCP patients with varying degrees of severity before delivery is crucial for diagnosing HDCP. Based on this, this article provides a retrospective analysis of studies on D-D and coagulation indicators in patients with hypertensive disorders during pregnancy, aimed at providing clinical support for the early prediction and treatment of high-risk perinatal women to reduce the incidence of adverse pregnancy outcomes, ultimately lowering maternal and neonatal mortality and morbidity rates.

KEYWORDS

D-D; Coagulation Indicators; HDCP; Diagnostic Value

CITE THIS PAPER

Liang Ming, Zhaofan Luo, Research on the Clinical Test Value of D-D and Coagulation Indicators in Patients with Hypertension during Pregnancy. MEDS Basic Medicine (2024) Vol. 2: 84-89. DOI: http://dx.doi.org/10.23977/medbm.2024.020212.

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