Author(s)

Chaoip Ng ¹, Claudia Gabriela Ho Cambeta ², Yanting Ip ³

Affiliation(s)

¹ Xiangya School of Medicine, Central South University, Changsha, 410083, China
² The Affiliated School of the University of Macau, Macao, 999078, China
³ School of Stomatology, Jinan University, Guangzhou, 510632, China

Corresponding Author

Yanting Ip

ABSTRACT

To study the diagnostic value of C-TIRADS and ACR-TIRADS for benign and malignant thyroid nodules. This study searched the Chinese databases CNKI, Wanfang, and VIP database for literature regarding the diagnosis of benign and malignant thyroid nodules by C-TIRADS and ACR-TIRADS, covering the period from June 2020 to June 2024. After screening, a total of 13 literature pieces were included, containing 5849 patients. The Cochrane bias risk assessment tool of RevMan5.3 software was used to assess the quality of the included literature. The combined sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, odds ratio, and heterogeneity were measured by Stata16.0 and RevMan5.3 software. The summary receiver operating characteristic (SROC) curve was drawn and the area under the curve (AUC) was calculated. Among the included cases, 7514 lesions were discovered 4329 were malignant (57.61% positive rate) and 3185 were benign (42.39% negative rate). The calculated C-TIRADS sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 0.91 (95%CI: 0.87-0.94), 0.80 (95%CI: 0.71~0.86), 4.5 (95%CI: 3.2-6.5), 0.11 (95%CI: 0.07-0.06), 42 (95%CI: 28-63), and the AUC was 0.93. The ACR-TIRADS sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 0.89 (95%CI: 0.82-0.93), 0.71 (95%CI: 0.61-0.79), 3.1 (95%CI: 2.3-4.1), 0.16 (95%CI: 0.10-0.26), 19 (95%CI: 11-35), and the AUC was 0.88. The heterogeneity test result for sensitivity was Q=182.52, df=12.00, P<0.00001, I2=93.43%, 95%CI(2.70,3.57). In Conclusion, compared to ACR-TIRADS, C-TIRADS technology has higher diagnostic performance for the judgment of benign and malignant thyroid nodules and is worth promoting in clinical practice.

KEYWORDS

C-TIRADS, ACR-TIRADS, Thyroid Nodules, Meta-analysis

CITE THIS PAPER

Chaoip Ng, Claudia Gabriela Ho Cambeta, Yanting Ip, The Application Value of C-TIRADS and ACR-TIRADS in the Diagnosis of Thyroid Nodules: A Meta-Analysis. MEDS Clinical Medicine (2024) Vol. 5: 86-94. DOI: http://dx.doi.org/10.23977/medsc.2024.050411.

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