Author(s)

Zhu Zhenyi ¹, Yongkang Yang ²

Affiliation(s)

¹ Shaanxi University of Chinese Medicine, Xianyang, 712046, China
² The Second Clinical Medical College, Shaanxi University of Chinese Medicine, Xianyang, 712000, China

Corresponding Author

Yongkang Yang

ABSTRACT

Vulvar lichen sclerosus (VLS) is a chronic, progressive dermatological condition characterized by recurrent episodes that often lead to persistent vulvar itching, pain, burning sensations, and in some cases, atrophy and scarring of the vulvar skin. These symptoms severely impact the patient's quality of life. Various treatments are used in clinical practice both domestically and internationally; however, due to the unknown etiology, prolonged disease course, difficulty in achieving a cure, and high recurrence rates, there is still a lack of effective therapies. The combined use of Traditional Chinese and Western medicine has shown certain advantages in alleviating symptoms, improving the disease course, and enhancing patients' quality of life. This article reviews the progress in research on the combined treatment of vulvar lichen sclerosus with Traditional Chinese and Western medicine, discusses the advantages of this integrative approach, and aims to provide new perspectives and methods for the treatment of VLS.

KEYWORDS

Vulvar Lichen Sclerosus; Integrated Traditional Chinese and Western Medicine

CITE THIS PAPER

Zhu Zhenyi, Yongkang Yang, Research Progress on the Combined Treatment of Vulvar Lichen Sclerosus with Traditional Chinese and Western Medicine. MEDS Clinical Medicine (2024) Vol. 5: 80-85. DOI: http://dx.doi.org/10.23977/medsc.2024.050410.

REFERENCES

[1] Neill, S. M., Lewis, F. M., Tatnall, F. M., Cox, N. H., & British Association of Dermatologists (2010). British Association of Dermatologists' guidelines for the management of lichen sclerosus 2010. The British journal of dermatology, 163(4), 672–682.
[2] Yeon, J., Oakley, A., Olsson, A., Drummond, C., Veysey, E., Marshman, G., Saunders, H., Opie, J., Bradford, J., Cole, J., DeAmbrosis, K., Cook, K., Pepall, L., Eva, L. J., Sladden, M., Selva-Nayagam, P., Phillips, R., Ball, S., Hill, S., Bohl, T., … Fischer, G. (2021). Vulval lichen sclerosus: An Australasian management consensus. The Australasian journal of dermatology, 62(3), 292–299. 
[3] Cheng Shiyu, Shi Jie, Li Yanli, & Gao Han. (2024). Clinical Research Progress of Vulvar Lichen Sclerosus. International Journal of Reproductive Health/Family Planning, (03), 260-264.
[4] Krapf, J. M., Mitchell, L., Holton, M. A., & Goldstein, A. T. (2020). Vulvar Lichen Sclerosus: Current Perspectives. International journal of women's health, 12, 11–20.
[5] Qu Hong, Wang Lei, Zheng Jun, & Zhang Bin. (2022). Clinical Observation of Focused Ultrasound Combined with Shencalming Lotion in the Treatment of Non-Neoplastic Vulvar Intraepithelial Lesions. Gansu Science and Technology, (13), 102-106.
[6] Li Qing, Huang Dongmei, Geng Jie, Yuan Wenna, Guo Fen, & Chen Yuanyuan. (2023). Efficacy Analysis of Fractional CO2_22 Laser Treatment for Vulvar Lichen Sclerosus. Chinese Journal of Practical Gynecology and Obstetrics, (04), 462-465.
[7] Wang Yukun & Liu Jie. (2024). Application Value of Photodynamic Therapy in Female Vulvar Lichen Sclerosus. Chinese Journal of Clinical Obstetrics and Gynecology, (02), 182-184.
[8] Kelamukalibinu'er, Xie Kun, Su Chenxiang, et al. Clinical Research Progress on Platelet-Rich Plasma in the Treatment of Vulvar Lichen Sclerosus [J]. Maternal and Child Health Guide, 2023, 2(24): 16-19.
[9] Sang Min & Chen Min. (2020). Clinical Observation of Manual Massage Combined with Infrared Bioeffect Technology in the Treatment of Non-Neoplastic Vulvar Intraepithelial Lesions. Journal of Harbin Medical University, (05), 516-518+522. 
[10] Fu Yanping, Yu Min, Liu Qionghui, Li Yan, Lü Shanshan, & Wu Xueping. (2022). Meta-Analysis of Traditional Chinese Medicine Combined with Focused Ultrasound in the Treatment of Vulvar Leukoplakia. Clinical Research in Traditional Chinese Medicine, (03), 82-86.
[11] Yang Shenghong, Liang Zhigang, & Xiao Yanbing. (2012). Efficacy Observation of a Homemade Traditional Chinese Medicine Ointment Compared with Halometasone Cream in the Treatment of Non-Neoplastic Vulvar Intraepithelial Lesions. Journal of Practical Obstetrics and Gynecology, (10), 869-872.
[12] Liu Yi & Deng Linwen. (2018). Effects of Guishao Zuogui Decoction on Liver and Kidney Yin Deficiency Type Vulvar Dystrophy and Its Impact on Immune Function. China Medical Herald, (16), 101-104.
[13] Liu Wensheng. (2017). Clinical Observation of 60 Cases of Non-Neoplastic Vulvar Intraepithelial Lesions Treated with a Self-Formulated Quban Decoction. Clinical Research in Traditional Chinese Medicine, (29), 106-108.
[14] Gui Wenjie, Wang Guiping, & Li Huiling. (2022). Treatment of 52 Cases of Vulvar Lichen Sclerosus with Acupuncture Combined with Traditional Chinese Medicine Sitz Baths. Hunan Journal of Traditional Chinese Medicine, (09), 69-71.
[15] Zhang Maoxiang, Yu Yang, Zhang Mingyang, Wang Fengyang, & Ai Min. (2023). Clinical Efficacy of Traditional Chinese Medicine Fumigation and Washing Combined with Local Manual Therapy in the Treatment of Senile Vulvar Leukoplakia. Chinese Journal of Gerontology, (06), 1360-1363.
[16] Huo Suming. (2020). Clinical Observation of Vulvar Leukoplakia Decoction Combined with Auricular Acupressure Seed Therapy in the Treatment of Vulvar Leukoplakia. Journal of Liaoning University of Traditional Chinese Medicine, (06), 194-197.
[17] Qin Shuhong, Chen Shijin, & Wei Qinfang. (2018). Study on the Effects of Moxibustion, Leukoplakia Ointment, and Baum Light Therapy in the Combined Treatment of Vulvar Leukoplakia. Clinical Research in Traditional Chinese Medicine, (27), 115-117.
[18] Jiang Junqing, Wang Guiping, Li Lingzhi, Li Hong, & Zhang Litao. (2017). Clinical Observation of the Combined Treatment of Vulvar Lichen Sclerosus with Traditional Chinese and Western Medicine. Chinese Journal of Dermatology and Venereology of Integrated Traditional and Western Medicine, (02), 147-148.
[19] Ma Li, Cheng Bo, Wei Huizhen, Feng Li, & Chen Ling. (2016). Observation of the Efficacy of Traditional Chinese Medicine Combined with Focused Ultrasound in the Treatment of Non-Neoplastic Vulvar Intraepithelial Lesions. World Chinese Medicine, (07), 1290-1293.
[20] Huang, Y.X., Ren, Q.L., Sun, F.D., & Zhu, S.C. (2017). Clinical observation of the efficacy of modified Shechuangzi powder combined with high-intensity focused ultrasound in the treatment of vulvar leukoplakia. Chinese Journal of Family Planning, (06), 404-407.
[21] Qu, H., Wang, L., Zheng, J., & Zhang, B. (2022). A single-center retrospective analysis of focused ultrasound combined with Shenju wash in the treatment of non-neoplastic vulvar intraepithelial lesions. Western Journal of Traditional Chinese Medicine, (07), 115-118.
[22] Zeng, L.J., & Zeng, L.Q. (2017). Observation on the efficacy of focused ultrasound combined with traditional Chinese medicine fumigation and washing in the treatment of non-neoplastic vulvar epithelial lesions. Jiangxi Medical Journal, (03), 246-248.
[23] Kang, L.L., & Wei, Q.L. (2019). Clinical experience of Director Wei Qinglin in treating vulvar dystrophy. Clinical Research in Traditional Chinese Medicine, (34), 43-45.
[24] Wang, J., & Lin, C.H. (2017). Evaluation of the efficacy of combined traditional Chinese and Western medicine in the treatment of vulvar leukoplakia. Journal of Practical Gynecological Endocrinology (Electronic Edition), (02), 47+49.
[25] He, X.M. (2015). Analysis of the efficacy of integrated traditional Chinese and Western medicine in treating vulvar leukoplakia. Contemporary Medicine, (20), 158-159.
[26] Yang, X.Y. (2013). Observation of the efficacy of integrated traditional Chinese and Western medicine in treating 74 cases of vulvar leukoplakia. Qinghai Medical Journal, (02), 60-61.

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