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  4. Vol 5, Issue 4, 2024

The Causal Relationships between Hyperthyroidism, Polyomavirus Infection, and Kidney Problems: A Mendelian Randomization Study

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DOI: 10.23977/medsc.2024.050405 | Downloads: 23 | Views: 672

Author(s)

Yuanhao Su 1, Yi Jin 2

Affiliation(s)

1 Department of General Surgery, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, China
2 Institute of Gene and Cell Therapy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China

Corresponding Author

Yi Jin

ABSTRACT

Studies have suggested a correlation between hyperthyroidism, polyomavirus infection, and kidney problems, but the causal relationships remain unclear. This research seeks to investigate the causal relationships between hyperthyroidism, polyomavirus infection, and kidney problems using Mendelian randomization (MR), providing insights for clinical treatment and prevention of these conditions. Genetic data for hyperthyroidism, polyomavirus infection, and kidney issues were sourced from GWAS and analyzed using MR in separate groups. Bidirectional studies were conducted to evaluate reverse causality, followed by sensitivity analyses to determine effect stability. In the genetic evaluation, a notable positive association was observed between hyperthyroidism and polyomavirus infection, hyperthyroidism and kidney problems, and polyomavirus infection and kidney problems. This correlation was consistent across four methods: Inverse Variance Weighted (IVW), MR Egger, Weighted Median, and Weighted Mode. Additionally, reverse MR analysis indicated no reverse causality and extra sensitivity studies showed similar MR assessment results with no horizontal pleiotropy. In summary, the results indicate that hyperthyroidism is a contributing factor to a higher occurrence of polyomavirus infection and kidney problems. Additionally, polyomavirus infection is a risk factor for an increased incidence of kidney problems.

KEYWORDS

Hyperthyroidism, Polyomavirus Infection, Kidney Problems, Mendelian Randomization, Causal Relationships

CITE THIS PAPER

Yuanhao Su, Yi Jin, The Causal Relationships between Hyperthyroidism, Polyomavirus Infection, and Kidney Problems: A Mendelian Randomization Study. MEDS Clinical Medicine (2024) Vol. 5: 41-50. DOI: http://dx.doi.org/10.23977/medsc.2024.050405.

REFERENCES

[1] Vargas-Uricoechea H (2023) Molecular Mechanisms in Autoimmune Thyroid Disease. Cells 12.
[2] De Leo S, Lee SY, Braverman LE (2016) Hyperthyroidism. Lancet 388: 906-918.
[3] Zimmermann MB, Boelaert K (2015) Iodine deficiency and thyroid disorders. Lancet Diabetes Endocrinol 3: 286-295.
[4] Smith TJ, Hegedüs L (2016) Graves' Disease. N Engl J Med 375: 1552-1565.
[5] McIver B, Morris JC (1998) The pathogenesis of Graves' disease. Endocrinol Metab Clin North Am 27: 73-89.
[6] Bartalena L (2013) Diagnosis and management of Graves disease: a global overview. Nat Rev Endocrinol 9: 724-734. 
[7] Ross DS, Burch HB, Cooper DS, Greenlee MC, Laurberg P, et al. (2016) 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis. Thyroid 26: 1343-1421.
[8] Ghareebian H, Mariash C (2022) COVID-19-Induced Graves' Disease. Cureus 14: e22260.
[9] Weider T, Genoni A, Broccolo F, Paulsen TH, Dahl-Jørgensen K, et al. (2022) High Prevalence of Common Human Viruses in Thyroid Tissue. Front Endocrinol (Lausanne) 13: 938633.
[10] Calvignac-Spencer S, Feltkamp MC, Daugherty MD, Moens U, Ramqvist T, et al. (2016) A taxonomy update for the family Polyomaviridae. Arch Virol 161: 1739-1750.
[11] Moens U, Krumbholz A, Ehlers B, Zell R, Johne R, et al. (2017) Biology, evolution, and medical importance of polyomaviruses: An update. Infect Genet Evol 54: 18-38.
[12] DeCaprio JA, Garcea RL (2013) A cornucopia of human polyomaviruses. Nat Rev Microbiol 11: 264-276.
[13] Gross L (1953) A filterable agent, recovered from Ak leukemic extracts, causing salivary gland carcinomas in C3H mice. Proc Soc Exp Biol Med 83: 414-421.
[14] Eddy BE, Borman GS, Grubbs GE, Young RD (1962) Identification of the oncogenic substance in rhesus monkey kidney cell culture as simian virus 40. Virology 17: 65-75.
[15] Gardner SD, Field AM, Coleman DV, Hulme B (1971) New human papovavirus (B.K.) isolated from urine after renal transplantation. Lancet 1: 1253-1257.
[16] Padgett BL, Walker DL, ZuRhein GM, Eckroade RJ, Dessel BH (1971) Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy. Lancet 1: 1257-1260.
[17] Feng H, Shuda M, Chang Y, Moore PS (2008) Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 319: 1096-1100.
[18] Knowles WA, Pipkin P, Andrews N, Vyse A, Minor P, et al. (2003) Population-based study of antibody to the human polyomaviruses BKV and JCV and the simian polyomavirus SV40. J Med Virol 71: 115-123.
[19] Furmaga J, Kowalczyk M, Zapolski T, Furmaga O, Krakowski L, et al. (2021) BK Polyomavirus-Biology, Genomic Variation and Diagnosis. Viruses 13.
[20] Hirsch HH, Knowles W, Dickenmann M, Passweg J, Klimkait T, et al. (2002) Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients. N Engl J Med 347: 488-496.
[21] de Bruyn G, Limaye AP (2004) BK virus-associated nephropathy in kidney transplant recipients. Rev Med Virol 14: 193-205.
[22] Bowden J, Davey Smith G, Haycock PC, Burgess S (2016) Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator. Genet Epidemiol 40: 304-314.
[23] Verbanck M, Chen CY, Neale B, Do R (2018) Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet 50: 693-698.
[24] Valtonen VV, Ruutu P, Varis K, Ranki M, Malkamäki M, et al. (1986) Serological evidence for the role of bacterial infections in the pathogenesis of thyroid diseases. Acta Med Scand 219: 105-111.
[25] Joasoo A, Robertson P, Murray IP (1975) Letter: Viral antibodies in thyrotoxicosis. Lancet 2: 125.
[26] Nagata K, Nakayama Y, Higaki K, Ochi M, Kanai K, et al. (2015) Reactivation of persistent Epstein-Barr virus (EBV) causes secretion of thyrotropin receptor antibodies (TRAbs) in EBV-infected B lymphocytes with TRAbs on their surface. Autoimmunity 48: 328-335.
[27] Bräunlich H (1984) Postnatal development of kidney function in rats receiving thyroid hormones. Exp Clin Endocrinol 83: 243-250. 
[28] Basu G, Mohapatra A (2012) Interactions between thyroid disorders and kidney disease. Indian J Endocrinol Metab 16: 204-213.
[29] Kobori H, Ichihara A, Miyashita Y, Hayashi M, Saruta T (1998) Mechanism of hyperthyroidism-induced renal hypertrophy in rats. J Endocrinol 159: 9-14.
[30] Kean JM, Rao S, Wang M, Garcea RL (2009) Seroepidemiology of human polyomaviruses. PLoS Pathog 5: e1000363.
[31] Balba GP, Javaid B, Timpone JG, Jr. (2013) BK polyomavirus infection in the renal transplant recipient. Infect Dis Clin North Am 27: 271-283.
[32] Umeda K, Kato I, Kawaguchi K, Tasaka K, Kamitori T, et al. (2018) High incidence of BK virus-associated hemorrhagic cystitis in children after second or third allogeneic hematopoietic stem cell transplantation. Pediatr Transplant 22: e13183.

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