Author(s)

Guangbo Zhang ¹

Affiliation(s)

¹ Occupational Diseases Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong Provinces, China

Corresponding Author

Guangbo Zhang

ABSTRACT

Pneumoconiosis is an occupational disease caused by long-term inhalation of dust particles, and the fibrosis process in the lungs is a critical stage of disease development, significantly affecting the patient's respiratory function and overall quality of life. Despite the existence of various treatment methods, the therapeutic effect of pneumoconiosis fibrosis is still unsatisfactory, and new treatment strategies are urgently needed to slow down or reverse the fibrosis process. This article first outlines the pathogenesis of pneumoconiosis fibrosis and the anti-fibrotic mechanism of tetrandrine, and then introduces the research design, experimental methods, and experimental process. Through prospective observational studies, this article systematically analyzed the intervention effect of tetrandrine on the progression of pulmonary fibrosis in patients with pneumoconiosis, and compared the changes in relevant indicators before and after treatment. The experimental results show that tetrandrine has shown good anti fibrotic effects in patients with pneumoconiosis. After a certain period of treatment, the degree of pulmonary fibrosis in patients has been significantly improved, and their respiratory function and quality of life have also been improved. Meanwhile, this article also observes that tetrandrine has a positive effect in regulating the levels of related inflammatory factors and cytkines, which helps to further slowdown or reverse the fibrosis process of pneumoconiosis.

KEYWORDS

Tetrandrine, Pneumoconiosis Fibrosis, Progression Observation, Prospective Research

CITE THIS PAPER

Guangbo Zhang, A Prospective Observational Study on the Effect of Tetrandrine on the Progression of Pneumoconiosis Fibrosis. MEDS Clinical Medicine (2024) Vol. 5: 136-144. DOI: http://dx.doi.org/10.23977/medsc.2024.050321.

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