Author(s)

Pian Kunkun ¹, Cheng Limin ¹

Affiliation(s)

¹ Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China

Corresponding Author

Cheng Limin

ABSTRACT

Ulcerative colitis is a chronic inflammatory bowel disease with complex clinical manifestations and significant treatment challenges. Traditional Chinese medicine (TCM) offers unique advantages in treating ulcerative colitis, yet its treatment mechanisms remain incompletely elucidated. Metabolomics technology, as a tool for comprehensive analysis of biological metabolites, has gradually been applied in ulcerative colitis research, providing new perspectives for understanding its pathogenesis and optimizing treatment strategies. This paper reviews the research progress on TCM treatment of ulcerative colitis based on metabolomics technology, discusses the application prospects and significance of metabolomics in TCM research, aiming to provide a theoretical foundation and methodological guidance for future in-depth studies.

KEYWORDS

Ulcerative colitis, Traditional Chinese medicine, Metabolomics, Treatment mechanisms, Research progress

CITE THIS PAPER

Pian Kunkun, Cheng Limin, Advances in the treatment of ulcerative colitis with Chinese medicine based on metabolomics technology. MEDS Chinese Medicine (2024) Vol. 6: 109-116. DOI: http://dx.doi.org/10.23977/medcm.2024.060214.

REFERENCES

[1] Wu Z, Chen Y, Zhu D, et al. Advancement of traditional Chinese medicine in regulation of intestinal flora: mechanism-based role in disease management[J]. Recent Patents on Anti-Cancer Drug Discovery, 2022, 17(2): 136-144. 
[2] Zhang, Chi, Miao Jiang, and Aiping Lu. "Considerations of traditional Chinese medicine as adjunct therapy in the management of ulcerative colitis." Clinical reviews in allergy & immunology 44 (2013): 274-283.
[3] Zheng, Shihao, et al. "Chinese medicine in the treatment of ulcerative colitis: the mechanisms of signaling pathway regulations." The American Journal of Chinese Medicine 50.07 (2022): 1781-1798. 
[4] Sałaga, Maciej, et al. "Chinese herbal medicines in the treatment of IBD and colorectal cancer: a review." Current treatment options in oncology 15 (2014): 405-420.
[5] Luo Y, Wu J, Liu Y, et al. Metabolomics study of Shaoyao plants decoction on the proximal and distal colon in mice with dextran sulfate sodium-induced colitis by UPLC-Q-TOF-MS[J]. Drug Design, Development and Therapy, 2022: 4343-4364.
[6] Zhou R, Huang Y, Tian C, et al. Coptis chinensis and berberine ameliorate chronic ulcerative colitis: An integrated microbiome-metabolomics study[J]. The American Journal of Chinese Medicine, 2023, 51(08): 2195-2220.
[7] Zhou G, Liu H, Wei P, et al. Amino acids-targeted metabolomics reveals novel diagnostic biomarkers for ulcerative colitis and Crohn’s disease[J]. Amino Acids, 2023, 55(3): 349-358.
[8] Dai, Yan-Cheng, et al. "A review of Qingchang Shuan for treatment of ulcerative colitis." Journal of Traditional Chinese Medicine 30.3 (2010): 237-240.

Sponsors, Associates, and Links

---

• MEDS Clinical Medicine
  
  
• Journal of Neurobiology and Genetics
  
  
• Medical Imaging and Nuclear Medicine
  
  
• Bacterial Genetics and Ecology
  
  
• Transactions on Cancer
  
  
• Journal of Biophysics and Ecology
  
  
• Journal of Animal Science and Veterinary
  
  
• Academic Journal of Biochemistry and Molecular Biology
  
  
• Transactions on Cell and Developmental Biology
  
  
• Rehabilitation Engineering & Assistive Technology
  
  
• Orthopaedics and Sports Medicine
  
  
• Hematology and Stem Cell
  
  
• Journal of Intelligent Informatics and Biomedical Engineering
  
  
• MEDS Basic Medicine
  
  
• MEDS Stomatology
  
  
• MEDS Public Health and Preventive Medicine
  
  
• Journal of Enzyme Engineering
  
  
• Advances in Industrial Pharmacy and Pharmaceutical Sciences
  
  
• Bacteriology and Microbiology
  
  
• Advances in Physiology and Pathophysiology
  
  
• Journal of Vision and Ophthalmology
  
  
• Frontiers of Obstetrics and Gynecology
  
  
• Digestive Disease and Diabetes
  
  
• Advances in Immunology and Vaccines
  
  
• Nanomedicine and Drug Delivery
  
  
• Cardiology and Vascular System
  
  
• Pediatrics and Child Health
  
  
• Journal of Reproductive Medicine and Contraception
  
  
• Journal of Respiratory and Lung Disease
  
  
• Journal of Bioinformatics and Biomedicine